Langerhans cells as macrophages in skin and lymphoid organs

G. J. Thorbecke, I. Silberberg-Sinakin, Thomas J Flotte

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic 'reticulum' cells included were indeterminate dendritic cells from the epidermis, interdigitating 'reticulum' cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of 'macrophages'. On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.

Original languageEnglish (US)
Pages (from-to)32-43
Number of pages12
JournalJournal of Investigative Dermatology
Volume75
Issue number1
StatePublished - 1980
Externally publishedYes

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Langerhans Cells
Macrophages
Dendritic Cells
Skin
Reticulum
Thymus
Epidermis
Thymus Gland
Follicular Dendritic Cells
Lymphokines
Antigen Presentation
Lymphoid Tissue
T-cells
Phagocytes
Prostaglandins
Lymph Nodes
T-Lymphocytes
Tissue
Antigens

ASJC Scopus subject areas

  • Dermatology

Cite this

Langerhans cells as macrophages in skin and lymphoid organs. / Thorbecke, G. J.; Silberberg-Sinakin, I.; Flotte, Thomas J.

In: Journal of Investigative Dermatology, Vol. 75, No. 1, 1980, p. 32-43.

Research output: Contribution to journalArticle

Thorbecke, GJ, Silberberg-Sinakin, I & Flotte, TJ 1980, 'Langerhans cells as macrophages in skin and lymphoid organs', Journal of Investigative Dermatology, vol. 75, no. 1, pp. 32-43.
Thorbecke, G. J. ; Silberberg-Sinakin, I. ; Flotte, Thomas J. / Langerhans cells as macrophages in skin and lymphoid organs. In: Journal of Investigative Dermatology. 1980 ; Vol. 75, No. 1. pp. 32-43.
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