TY - JOUR
T1 - Langerhans cells as macrophages in skin and lymphoid organs
AU - Thorbecke, G. J.
AU - Silberberg-Sinakin, I.
AU - Flotte, T. J.
N1 - Funding Information:
The work on which this review has been based was performed with support from U. S. Public Health Service Grants AI-03076, Al-11103, and AM-26091. Reprint requests to: G. Jeanette Thorbecke, M.D., Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Abbreviations: DRCs: dendritic reticulum cells LCs: Langerhans cells L-dopa: naturally occurring form of 3,4-dihydroxyphenylalanine 2-ME: 2-mercaptoethanol inner PALS: inner portion of the periarteriolar lymphatic sheath RCs: "reticulum" cells UVL: ultraviolet light
PY - 1980
Y1 - 1980
N2 - Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic 'reticulum' cells included were indeterminate dendritic cells from the epidermis, interdigitating 'reticulum' cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of 'macrophages'. On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.
AB - Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic 'reticulum' cells included were indeterminate dendritic cells from the epidermis, interdigitating 'reticulum' cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of 'macrophages'. On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.
UR - http://www.scopus.com/inward/record.url?scp=0018897069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018897069&partnerID=8YFLogxK
U2 - 10.1111/1523-1747.ep12521083
DO - 10.1111/1523-1747.ep12521083
M3 - Article
C2 - 6993584
AN - SCOPUS:0018897069
SN - 0022-202X
VL - 75
SP - 32
EP - 43
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -