Lactic acid: No longer an inert and end-product of glycolysis

Shiren Sun, Heng Li, Jianghua Chen, Qi Qian

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20 + years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.

Original languageEnglish (US)
Article numberA008
Pages (from-to)453-463
Number of pages11
JournalPhysiology
Volume32
Issue number6
DOIs
StatePublished - Oct 11 2017

ASJC Scopus subject areas

  • Physiology

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