TY - JOUR
T1 - Lactic acid
T2 - No longer an inert and end-product of glycolysis
AU - Sun, Shiren
AU - Li, Heng
AU - Chen, Jianghua
AU - Qian, Qi
N1 - Publisher Copyright:
© 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2017/10/11
Y1 - 2017/10/11
N2 - For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20 + years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.
AB - For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20 + years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.
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U2 - 10.1152/physiol.00016.2017
DO - 10.1152/physiol.00016.2017
M3 - Review article
C2 - 29021365
AN - SCOPUS:85031313826
SN - 1548-9213
VL - 32
SP - 453
EP - 463
JO - Physiology
JF - Physiology
IS - 6
M1 - A008
ER -