Abstract
The PDA: TO LEave it alone or Respond And Treat Early trial compared the effects of 2 strategies for treatment of patent ductus arteriosus (PDA) in infants <280/7 weeks of gestation; however 137 potentially eligible infants were not recruited and received treatment of their PDA outside the PDA-TOLERATE trial due to “lack-of-physician-equipoise” (LPE). Despite being less mature and needing more respiratory support, infants with LPE had lower rates of mortality than enrolled infants. Infants with LPE treated before day 6 had lower rates of late respiratory morbidity than infants with LPE treated ≥day 6. Trial registration: ClinicalTrials.gov: NCT01958320.
Original language | English (US) |
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Pages (from-to) | 222-226.e2 |
Journal | Journal of Pediatrics |
Volume | 213 |
DOIs | |
State | Published - Oct 2019 |
Keywords
- bronchopulmonary dysplasia
- patent ductus arteriosus
- premature birth
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health