Lack of effect of gastric inhibitory polypeptide on hepatic and extrahepatic insulin action

F. J. Service, V. J. Heiling, V. L.W. Go, R. A. Rizza

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

To assess the influence of enteric factors on insulin action, seven lean healthy subjects were studied under conditions of hyperinsulinemic euglycemic glucose clamp, double isotope administration, and enteral vs. parenteral glucose infusion. In random order, glucose and mannitol radiolabeled with [2-3H]glucose were infused intraduodenally for 4 h while the systemic rate of glucose turnover was assessed by [6-14C]glucose. During the final hour of the study, plasma glucose, insulin, C-peptide, glucagon, cholecystokinin, and neurotensin were similar under both experimental conditions. Despite an increase in gastric inhibitory polypeptide concentration during combined enteral and iv glucose infusion to levels that mimicked meal ingestion, total glucose infusion rate, insulin-induced stimulation of glucose uptake, and insulin-induced suppression of hepatic glucose release were comparable to those observed during v glucose administration. These data indicate that under con-ditions of modest hyperinsulinemia and euglycemia, gastric inhibitory polypeptide did not influence hepatic or extrahepatic insulin action.

Original languageEnglish (US)
Pages (from-to)1398-1402
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume70
Issue number5
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Lack of effect of gastric inhibitory polypeptide on hepatic and extrahepatic insulin action'. Together they form a unique fingerprint.

  • Cite this