Lack of benefit of intravenous immune globulin in a murine model of group A streptococcal necrotizing fasciitis

Robin Patel, Mark S. Rouse, Monica V. Florez, Kerryl E. Piper, Franklin R. Cockerill, Walter R. Wilson, James M. Steckelberg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin- S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P < .05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P = .02), penicillin/clindamycin (P = .009), clindamycin/IVIG (P = .04), or all agents combined (P = .02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number1
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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