TY - JOUR
T1 - Lack of benefit of intravenous immune globulin in a murine model of group A streptococcal necrotizing fasciitis
AU - Patel, Robin
AU - Rouse, Mark S.
AU - Florez, Monica V.
AU - Piper, Kerryl E.
AU - Cockerill, Franklin R.
AU - Wilson, Walter R.
AU - Steckelberg, James M.
N1 - Funding Information:
Received 4 June 1999; revised 7 September 1999; electronically published 20 December 1999. Presented in part: 98th General Meeting of the American Society for Microbiology, Atlanta, May 1998 (abstract A-76). Grant support: This study was supported by a grant from Alpha Therapeutic, Los Angeles, and by the Mayo Clinic and Foundation. Reprints or correspondence: Dr. Robin Patel, Division of Infectious Diseases and Dept. of Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (patel.robin@mayo.edu).
PY - 2000
Y1 - 2000
N2 - Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin- S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P < .05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P = .02), penicillin/clindamycin (P = .009), clindamycin/IVIG (P = .04), or all agents combined (P = .02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.
AB - Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin- S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P < .05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P = .02), penicillin/clindamycin (P = .009), clindamycin/IVIG (P = .04), or all agents combined (P = .02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.
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U2 - 10.1086/315198
DO - 10.1086/315198
M3 - Article
C2 - 10608771
AN - SCOPUS:0033955010
SN - 0022-1899
VL - 181
SP - 230
EP - 234
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -