Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation

C. V. Paya, R. H. Wiesner, P. E. Hermans, J. J. Larson-Keller, D. M. Ilstrup, R. A F Krom, S. B. Moore, J. Ludwig, T. F. Smith

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Abstract

In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection. A total of 81 consecutive liver transplant recipients were studied. Cytomegalovirus infection developed in 46 recipients (57%), and vanishing bile duct syndrome occurred in 9 recipients (11%). Cytomegalovirus infection developed in only five of the nine patients with vanishing bile duct syndrome. Univariate analysis of pretransplant recipient/donor cytomegalovirus serological tests and human leukocyte antigen typing showed they were not significant risk factors for the development of vanishing bile duct syndrome. Time-dependent analysis of cytomegalovirus infection after transplantation as a risk factor for vanishing bile duct syndrome, in a multivariate analysis with human leukocyte antigen match, showed no statistical significance. In our study, no association was found between cytomegalovirus infection alone or in relation to class I or II human leukocyte antigen match and the subsequent development of vanishing bile duct syndrome.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalHepatology
Volume16
Issue number1
DOIs
StatePublished - 1992

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ASJC Scopus subject areas

  • Hepatology

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Paya, C. V., Wiesner, R. H., Hermans, P. E., Larson-Keller, J. J., Ilstrup, D. M., Krom, R. A. F., Moore, S. B., Ludwig, J., & Smith, T. F. (1992). Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation. Hepatology, 16(1), 66-70. https://doi.org/10.1002/hep.1840160113