Lack of absorption of a sustained-release buprenorphine formulation administered subcutaneously to athymic nude rats

Agriculture & Biology

• buprenorphine 100%
• tandem mass spectrometry 37%
• rats 34%
• plasma cells 32%
• Institutional Animal Care and Use Committee 22%
• lymphocytes 21%
• skin (animal) 20%
• xenotransplantation 18%
• nonsteroidal anti-inflammatory agents 17%
• metastasis 16%
• Rattus norvegicus 15%
• analgesics 15%
• breast neoplasms 15%
• spine (bones) 14%
• spinal cord 14%
• shoulders 14%
• histopathology 14%
• cell-mediated immunity 14%
• liquid chromatography 13%
• connective tissues 13%
• pharmacokinetics 12%
• T-lymphocytes 12%
• macrophages 11%
• blood vessels 10%
• mouth 10%
• neoplasms 10%
• fluids 9%
• protocols 9%
• brain 9%
• mice 7%
• tissues 5%
• animals 5%
• water 5%