Knowledge gaps persist and hinder progress in eliminating mumps

R. Ramanathan, E. A. Voigt, R. B. Kennedy, G. A. Poland

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Mumps, a common childhood disease in the pre-vaccine era that causes swelling of the parotid salivary glands, can lead to orchitis, viral meningitis, and sensorineural deafness. While the incidence of disease decreased dramatically after the vaccine was added to standard vaccination schedules, the disease has made a substantial resurgence in recent years. As a result, it becomes critical to examine the factors involved in recurring outbreaks. Although low and incomplete vaccination coverage may be a key reason, it does not fully explain the issue due to the high rate of occurrence in populations with high vaccination coverage rates. Multiple studies suggest that waning immunity and secondary vaccine failure play a large role, the effects of which were previously masked by subclinical boosting. Significant knowledge gaps persist around the exact role and mechanism of waning immunity and demonstrate the need for more research in this area, as well as a reevaluation of mumps vaccine policy.

Original languageEnglish (US)
Pages (from-to)3721-3726
Number of pages6
JournalVaccine
Volume36
Issue number26
DOIs
StatePublished - Jun 18 2018

Keywords

  • Antibodies
  • Cytokines
  • Immunity, humoral
  • Measles-mumps-rubella vaccine
  • Mumps
  • Mumps vaccine
  • Mumps virus
  • Polymorphism, genetic
  • Receptors, cytokine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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