KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities

Irina Maric, Jamie Robyn, Dean D. Metcalfe, Michael P. Fay, Melody Carter, Todd Wilson, Weiming Fu, Jennifer Stoddard, Linda Scott, Marilyn Hartsell, Arnold Kirshenbaum, Cem Akin, Thomas B. Nutman, Pierre Noel, Amy D. Klion

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Background: The broad and overlapping clinical manifestations of D816V KIT-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia (CEL), coupled with the increase in activated eosinophils and mast cells seen in both disorders, have led to confusion in the nomenclature. It is of paramount importance, however, to distinguish between these 2 groups of patients because of differences in clinical sequelae, prognoses, and selection of treatment. Objective: We thus sought to identify clinical and laboratory features that could be used to distinguish these 2 diagnoses. Methods: We compared 12 patients with D816V-positive systemic mastocytosis with eosinophilia with 17 patients with FIP1L1/PDGFRA-positive CEL. Distinguishing features were used to create a risk factor scoring system. Results: This system correctly classified 16 of 17 FIP1L1/PDGFRA-positive patients with CEL and all 12 patients with systemic mastocytosis with eosinophilia. Thirty-four FIP1L1/PDGFRA-positive patients described in the literature were also classified using this system, and although a complete set of data was not available for any of the historical patients, 21 were correctly classified. Conclusion: These results reinforce the hypothesis that the FIP1L1/PDGFRA gene fusion and D816V-KIT mutation cause distinct clinical syndromes. Clinical implications: This novel diagnostic approach should prove helpful in clinical practice in the evaluation of patients with increased mast cells and peripheral eosinophilia.

Original languageEnglish (US)
Pages (from-to)680-687
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume120
Issue number3
DOIs
StatePublished - Sep 1 2007

Keywords

  • FIP1L1/PDGFRA
  • HES
  • KIT D816V mutation
  • Systemic mastocytosis
  • eosinophilia
  • hypereosinophilic syndrome
  • imatinib
  • mast cell disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities'. Together they form a unique fingerprint.

  • Cite this

    Maric, I., Robyn, J., Metcalfe, D. D., Fay, M. P., Carter, M., Wilson, T., Fu, W., Stoddard, J., Scott, L., Hartsell, M., Kirshenbaum, A., Akin, C., Nutman, T. B., Noel, P., & Klion, A. D. (2007). KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. Journal of Allergy and Clinical Immunology, 120(3), 680-687. https://doi.org/10.1016/j.jaci.2007.05.024