Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol

Sadia Choudhery, Shinn Huey S. Chou, Ken Chang, Jayashree Kalpathy-Cramer, Constance D. Lehman

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives: We implemented a rapid abridged multiphase (RAMP) breast magnetic resonance imaging (MRI) protocol to reduce scan time and increase workflow efficiency. In this study, we compared delayed-phase kinetic analyses of benign and malignant lesions on the RAMP protocol versus a full dynamic contrast-enhanced (DCE) MRI protocol. Materials and Methods: Consecutive breast MRI examinations obtained from October 2015 to August 2016 with tissue diagnoses of suspicious MRI lesions were identified. RAMP MRI included one precontrast and two postcontrast phases. Full DCE MRI included one precontrast and at least three postcontrast phases. Lesion kinetic analyses including mean delayed-phase volume percentage of washout, predominant curve type, and worst curve type were assessed. Kinetic analyses assessed on RAMP and DCE MRI protocols were compared using Wilcoxon rank-sum test and Chi-Square test. Receiver operating characteristic analysis was performed to discriminate benign and malignant lesions based on delayed-phase parameters. Results: The study included 177 consecutive breast lesions (50 benign, 127 malignant) in 162 women. RAMP MRI (23 benign, 61 malignant) and DCE MRI examinations (27 benign, 66 malignant) demonstrated 8.4% vs 9.3% washout (p = 0.36) for benign lesions and 18.5% vs 17% washout (p = 0.66) for malignancies, respectively. There was no difference in the predominant and worst curve types for malignant and benign lesions or in area under the receiver operating characteristic curves for delayed-phased parameters between the two protocols (p > 0.05). Conclusion: Lesion kinetic analyses from the RAMP MRI protocol can achieve the same discriminatory ability as the full DCE protocol. By reducing scan time, the RAMP MRI protocol improves patient comfort and enhances workflow efficiency and can be easily implemented in any clinical setting.

Original languageEnglish (US)
JournalAcademic radiology
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Breast
Magnetic Resonance Imaging
Workflow
Nonparametric Statistics
ROC Curve
Chi-Square Distribution

Keywords

  • abbreviated breast MRI protocol
  • breast cancer
  • Breast MRI
  • kinetic analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Choudhery, S., Chou, S. H. S., Chang, K., Kalpathy-Cramer, J., & Lehman, C. D. (Accepted/In press). Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol. Academic radiology. https://doi.org/10.1016/j.acra.2019.05.001

Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol. / Choudhery, Sadia; Chou, Shinn Huey S.; Chang, Ken; Kalpathy-Cramer, Jayashree; Lehman, Constance D.

In: Academic radiology, 01.01.2019.

Research output: Contribution to journalArticle

Choudhery, Sadia ; Chou, Shinn Huey S. ; Chang, Ken ; Kalpathy-Cramer, Jayashree ; Lehman, Constance D. / Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol. In: Academic radiology. 2019.
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abstract = "Rationale and Objectives: We implemented a rapid abridged multiphase (RAMP) breast magnetic resonance imaging (MRI) protocol to reduce scan time and increase workflow efficiency. In this study, we compared delayed-phase kinetic analyses of benign and malignant lesions on the RAMP protocol versus a full dynamic contrast-enhanced (DCE) MRI protocol. Materials and Methods: Consecutive breast MRI examinations obtained from October 2015 to August 2016 with tissue diagnoses of suspicious MRI lesions were identified. RAMP MRI included one precontrast and two postcontrast phases. Full DCE MRI included one precontrast and at least three postcontrast phases. Lesion kinetic analyses including mean delayed-phase volume percentage of washout, predominant curve type, and worst curve type were assessed. Kinetic analyses assessed on RAMP and DCE MRI protocols were compared using Wilcoxon rank-sum test and Chi-Square test. Receiver operating characteristic analysis was performed to discriminate benign and malignant lesions based on delayed-phase parameters. Results: The study included 177 consecutive breast lesions (50 benign, 127 malignant) in 162 women. RAMP MRI (23 benign, 61 malignant) and DCE MRI examinations (27 benign, 66 malignant) demonstrated 8.4{\%} vs 9.3{\%} washout (p = 0.36) for benign lesions and 18.5{\%} vs 17{\%} washout (p = 0.66) for malignancies, respectively. There was no difference in the predominant and worst curve types for malignant and benign lesions or in area under the receiver operating characteristic curves for delayed-phased parameters between the two protocols (p > 0.05). Conclusion: Lesion kinetic analyses from the RAMP MRI protocol can achieve the same discriminatory ability as the full DCE protocol. By reducing scan time, the RAMP MRI protocol improves patient comfort and enhances workflow efficiency and can be easily implemented in any clinical setting.",
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