It takes a village to overcome kras dependence in pancreatic cancer

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue, Hou and colleagues present their exciting work demonstrating that, through remodeling of the local tumor microenvironment (TME), pancreatic ductal adenocarcinoma forms a tumor-supportive niche capable of liberating cancer cells from dependence on oncogenic KRAS signaling. Through extensive experimenta-tion both in vitro and in vivo, the authors reveal that the HDAC5–CCL2 axis drives the recruitment of tumor-associated macrophages to the TME to provide trophic signaling.

Original languageEnglish (US)
Pages (from-to)910-912
Number of pages3
JournalCancer discovery
Volume10
Issue number7
DOIs
StatePublished - 2020

ASJC Scopus subject areas

  • Oncology

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