Abstract
In this issue, Hou and colleagues present their exciting work demonstrating that, through remodeling of the local tumor microenvironment (TME), pancreatic ductal adenocarcinoma forms a tumor-supportive niche capable of liberating cancer cells from dependence on oncogenic KRAS signaling. Through extensive experimenta-tion both in vitro and in vivo, the authors reveal that the HDAC5–CCL2 axis drives the recruitment of tumor-associated macrophages to the TME to provide trophic signaling.
Original language | English (US) |
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Pages (from-to) | 910-912 |
Number of pages | 3 |
Journal | Cancer discovery |
Volume | 10 |
Issue number | 7 |
DOIs | |
State | Published - 2020 |
ASJC Scopus subject areas
- Oncology