TY - JOUR
T1 - Isolated Left Ventricular Basal Ballooning Phenotype of Transient Cardiomyopathy in Young Women
AU - Reuss, Christina S.
AU - Lester, Steven J.
AU - Hurst, R. Todd
AU - Askew, J. Wells
AU - Nager, Paul
AU - Lusk, Joan
AU - Altemose, Gregory T.
AU - Tajik, A. Jamil
PY - 2007/5/15
Y1 - 2007/5/15
N2 - This report describes a variant of transient regional left ventricular dysfunction in which isolated basal left ventricular akinesia with normal mid-ventricular (papillary-level) wall motion and apical hypercontractility were noted in young women (mean age 31 years). This finding was demonstrated in 3 consecutive patients; the first patient was experiencing emotional life-altering events, and the second presented with an acute flare of multiple sclerosis. The third patient presented <24 hours after methamphetamine use. Coronary angiography demonstrated normal epicardial coronary arteries in all patients. Wall motion abnormalities resolved within 2 to 6 weeks. In conclusion, the entity described in this report is reminiscent of apical ballooning ("Tako-Tsubo"), mid-ventricular ballooning, and apical sparing syndromes; however, isolated basal left ventricular involvement has not been previously described and is a newer variant in the spectrum of transient cardiomyopathies. The pathophysiology of this entity has not been elucidated. A unifying feature between the transient cardiomyopathic syndromes most likely is in the concentration, distribution, and activity of cardiac adrenergic receptors.
AB - This report describes a variant of transient regional left ventricular dysfunction in which isolated basal left ventricular akinesia with normal mid-ventricular (papillary-level) wall motion and apical hypercontractility were noted in young women (mean age 31 years). This finding was demonstrated in 3 consecutive patients; the first patient was experiencing emotional life-altering events, and the second presented with an acute flare of multiple sclerosis. The third patient presented <24 hours after methamphetamine use. Coronary angiography demonstrated normal epicardial coronary arteries in all patients. Wall motion abnormalities resolved within 2 to 6 weeks. In conclusion, the entity described in this report is reminiscent of apical ballooning ("Tako-Tsubo"), mid-ventricular ballooning, and apical sparing syndromes; however, isolated basal left ventricular involvement has not been previously described and is a newer variant in the spectrum of transient cardiomyopathies. The pathophysiology of this entity has not been elucidated. A unifying feature between the transient cardiomyopathic syndromes most likely is in the concentration, distribution, and activity of cardiac adrenergic receptors.
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U2 - 10.1016/j.amjcard.2006.12.078
DO - 10.1016/j.amjcard.2006.12.078
M3 - Article
C2 - 17493478
AN - SCOPUS:34247619812
SN - 0002-9149
VL - 99
SP - 1451
EP - 1453
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -