Isolated cardiac sarcoidosis: A focused review of an under-recognized entity

David R. Okada; Paco E. Bravo; Tomas Vita; Vikram Agarwal; Michael T. Osborne; Viviany R. Taqueti; Hicham Skali; Panithaya Chareonthaitawee; Sharmila Dorbala; Garrick Stewart; Marcelo Di Carli; Ron Blankstein

doi:10.1007/s12350-016-0658-1

Isolated cardiac sarcoidosis: A focused review of an under-recognized entity

David R. Okada, Paco E. Bravo, Tomas Vita, Vikram Agarwal, Michael T. Osborne, Viviany R. Taqueti, Hicham Skali, Panithaya Chareonthaitawee, Sharmila Dorbala, Garrick Stewart, Marcelo Di Carli, Ron Blankstein

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS. This review will summarize the available data related to the prevalence and prognosis of ICS and will discuss challenges surrounding the diagnosis and management of this under-recognized entity.

Original language	English (US)
Pages (from-to)	1136-1146
Number of pages	11
Journal	Journal of Nuclear Cardiology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s12350-016-0658-1
State	Published - Aug 1 2018

Keywords

Cardiac sarcoidosis
cardiac MRI
cardiac PET

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s12350-016-0658-1

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title = "Isolated cardiac sarcoidosis: A focused review of an under-recognized entity",

abstract = "There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS. This review will summarize the available data related to the prevalence and prognosis of ICS and will discuss challenges surrounding the diagnosis and management of this under-recognized entity.",

keywords = "Cardiac sarcoidosis, cardiac MRI, cardiac PET",

author = "Okada, {David R.} and Bravo, {Paco E.} and Tomas Vita and Vikram Agarwal and Osborne, {Michael T.} and Taqueti, {Viviany R.} and Hicham Skali and Panithaya Chareonthaitawee and Sharmila Dorbala and Garrick Stewart and {Di Carli}, Marcelo and Ron Blankstein",

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year = "2018",

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doi = "10.1007/s12350-016-0658-1",

language = "English (US)",

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T2 - A focused review of an under-recognized entity

AU - Okada, David R.

AU - Bravo, Paco E.

AU - Vita, Tomas

AU - Agarwal, Vikram

AU - Osborne, Michael T.

AU - Taqueti, Viviany R.

AU - Skali, Hicham

AU - Chareonthaitawee, Panithaya

AU - Dorbala, Sharmila

AU - Stewart, Garrick

AU - Di Carli, Marcelo

AU - Blankstein, Ron

PY - 2018/8/1

Y1 - 2018/8/1

N2 - There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS. This review will summarize the available data related to the prevalence and prognosis of ICS and will discuss challenges surrounding the diagnosis and management of this under-recognized entity.

AB - There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS. This review will summarize the available data related to the prevalence and prognosis of ICS and will discuss challenges surrounding the diagnosis and management of this under-recognized entity.

KW - Cardiac sarcoidosis

KW - cardiac MRI

KW - cardiac PET

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JO - Journal of Nuclear Cardiology

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Isolated cardiac sarcoidosis: A focused review of an under-recognized entity

Abstract

Keywords

ASJC Scopus subject areas

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