Ischemia-reperfusion does not affect reactivity of isolated canine basilar artery

Zvonimir S. Katušić, John D. Michenfelder, James H. Milde

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effect of isehemia-reperfusion on endothelium-dependent relaxations and reactivity of vascular smooth-muscle cells was studied in rings of basilar arteries obtained from six dogs exposed to 12 min of complete global cerebral ischemia followed by 100 min of reperfusion. Three sham-operated control dogs served as controls. Ischemia was induced either by an increase in intracranial pressure or by aortic occlusion. The rings were suspended for isometric tension recording in physiological salt solution. Isehemia-reperfusion did not affect endothelium-dependent relaxations to vasopressin and bradykinin. In rings without endothelium relaxations to sodium nitroprusside, molsidomine (SIN-1), and papaverine as well as contractions to 5-hydroxytryptamine and KCl were preserved. These results demonstrate that in large canine cerebral arteries, ischemia-reperfusion of these durations does not affect relaxations mediated by activation of endothelium or direct relaxations and contractions of vascular smooth-muscle cells.

Original languageEnglish (US)
Pages (from-to)824-828
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume11
Issue number5
DOIs
StatePublished - Jan 1 1991

Keywords

  • Bradykinin
  • Cerebral arteries
  • EDRF
  • Nitric oxide
  • Reperfusion injury
  • Vasopressin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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