Is the postovulatory release of follicle-stimulating hormone in the rabbit mediated by luteinizing hormone-releasing hormone?

T. M. Mills, John A III Copland, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injecton of this barbiturate had no measurable effect on the postovulatory FSH secretion pattern. Administration of the LHRH antagomist [Ac-D-p-Cl-Phe1,2, Phe3, D-Arg6, D-Ala10]LHRH (0.5 mg/doe) prevented all gonadotropin release in response to LHRH injection (10 μg/kg BW). When this same dose of the antagonist was injected at 18 h postcoitum, the postovulatory FSH secretion pattern was unaffected. Finally, to prove that the pituitary was sensitive to LHRH at 18-h postcoitum, LHRH (10 μg/kg BW) was injected into rabbits mated 18 h earlier; this treatment led to a marked increase in FSH secretion showing that the pituitary is responsive to LHRH at this time. The results of this study show that two drugs which block LHRH-mediated gonadotropin release have no effect on the postovulatory secretion of FSH and support the concept that this episode of FSH secretion occurs via a pathway which does not include the hypothalamic secretion of LHRH.

Original languageEnglish (US)
Pages (from-to)1020-1024
Number of pages5
JournalEndocrinology
Volume113
Issue number3
StatePublished - 1983
Externally publishedYes

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Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Rabbits
Gonadotropins
Pentobarbital
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Is the postovulatory release of follicle-stimulating hormone in the rabbit mediated by luteinizing hormone-releasing hormone? / Mills, T. M.; Copland, John A III; Coy, D. H.; Schally, A. V.

In: Endocrinology, Vol. 113, No. 3, 1983, p. 1020-1024.

Research output: Contribution to journalArticle

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