TY - CHAP
T1 - Irritable bowel syndrome
T2 - Pathophysiology and current therapeutic approaches
AU - Camilleri, Michael
AU - Ford, Alexander C.
N1 - Publisher Copyright:
© Springer International Publishing AG 2016.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Irritable bowel syndrome (IBS) is a prevalent condition affecting 10-20% of adults in most countries; IBS results in significant morbidity and health care costs. IBS is a disorder of the brain-gut axis, and recent insights into the pathophysiological mechanisms include altered bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier, and secretory properties of the gut. There remains a significant unmet need for effective treatments, particularly for the pain component of IBS, although the introduction of drugs directed at secretion, motility, and a nonabsorbable antibiotic provides an option for the bowel dysfunction in IBS.
AB - Irritable bowel syndrome (IBS) is a prevalent condition affecting 10-20% of adults in most countries; IBS results in significant morbidity and health care costs. IBS is a disorder of the brain-gut axis, and recent insights into the pathophysiological mechanisms include altered bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier, and secretory properties of the gut. There remains a significant unmet need for effective treatments, particularly for the pain component of IBS, although the introduction of drugs directed at secretion, motility, and a nonabsorbable antibiotic provides an option for the bowel dysfunction in IBS.
KW - Irritable bowel syndrome
KW - Pharmacotherapy
UR - http://www.scopus.com/inward/record.url?scp=85018526692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018526692&partnerID=8YFLogxK
U2 - 10.1007/164_2016_102
DO - 10.1007/164_2016_102
M3 - Chapter
C2 - 27995391
AN - SCOPUS:85018526692
T3 - Handbook of Experimental Pharmacology
BT - Handbook of Experimental Pharmacology
PB - Springer New York LLC
ER -