Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal

Gregory L. Lyford, Gianrico Farrugia

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A requirement for normal gastrointestinal motility is the tight regulation of ion channels expressed in interstitial cells of Cajal and smooth muscle. Interstitial cells of Cajal generate the slow wave and amplify neuronal signals; smooth muscle functions as the final effector organ. Recent advances in our understanding of the expression and mechano-regulation of these different subtypes of ion channels have allowed the development of hypotheses on how ion channels transduce a variety of inputs into electrical signals that directly or indirectly regulate gastrointestinal motor activity.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume3
Issue number6
DOIs
StatePublished - Dec 2003

Fingerprint

Interstitial Cells of Cajal
Ion Channels
Smooth Muscle Myocytes
Smooth Muscle
Gastrointestinal Motility
Motor Activity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal. / Lyford, Gregory L.; Farrugia, Gianrico.

In: Current Opinion in Pharmacology, Vol. 3, No. 6, 12.2003, p. 583-587.

Research output: Contribution to journalArticle

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