Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal

Gregory L. Lyford, Gianrico Farrugia

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

A requirement for normal gastrointestinal motility is the tight regulation of ion channels expressed in interstitial cells of Cajal and smooth muscle. Interstitial cells of Cajal generate the slow wave and amplify neuronal signals; smooth muscle functions as the final effector organ. Recent advances in our understanding of the expression and mechano-regulation of these different subtypes of ion channels have allowed the development of hypotheses on how ion channels transduce a variety of inputs into electrical signals that directly or indirectly regulate gastrointestinal motor activity.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume3
Issue number6
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal'. Together they form a unique fingerprint.

  • Cite this