Involvement of oxidation-sensitive mechanisms in the cardiovascular effects of hypercholesterolemia

Claudio Napoli, Lilach O Lerman

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Hypercholesterolemia is a common clinical metabolic and/or genetic disorder that promotes functional and structural vascular wall injury. The underlying mechanisms for these deleterious effects involve a local inflammatory response and release of cytokines and growth factors. Consequent activation of oxidation-sensitive mechanisms in the arterial wall, modulation of intracellular signaling pathways, increased oxidation of low-density lipoprotein cholesterol, and quenching of nitric oxide can all impair the functions controlled by the vascular wall and lead to the development of atherosclerosis. This cascade represents a common pathological mechanism activated by various cardiovascular risk factors and may partly underlie synergism among them as well as the early pathogenesis of atherosclerosis. Antioxidant intervention and restoration of the bioavailability of nitric oxide have been shown to mitigate functional and structural arterial alterations and improve cardiovascular outcomes. Elucidation of the precise nature and role of early transductional signaling pathways and transcriptional events activated in hypercholesterolemia in children and adults, including mothers during pregnancy, and understanding their downstream effects responsible for atherogenesis may help in directing preventive and interventional measures against atherogenesis and vascular dysfunction.

Original languageEnglish (US)
Pages (from-to)619-631
Number of pages13
JournalMayo Clinic Proceedings
Volume76
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Hypercholesterolemia
Atherosclerosis
Blood Vessels
Nitric Oxide
Inborn Genetic Diseases
Vascular System Injuries
LDL Cholesterol
Biological Availability
Intercellular Signaling Peptides and Proteins
Antioxidants
Mothers
Cytokines
Pregnancy

Keywords

  • CHD = coronary heart disease
  • eNOS = endothelial nitric oxide synthase
  • HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A
  • IL = interleukin
  • iNOS = inducible nitric oxide synthase
  • LAD = left anterior descending
  • LDL = low-density lipoprotein
  • NADPH = nicotine adenine dinucleotide phosphate
  • NFκB = nuclear factor κ B
  • NO = nitric oxide
  • NOS = nitric oxide synthase
  • ROS = reactive oxygen species

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Involvement of oxidation-sensitive mechanisms in the cardiovascular effects of hypercholesterolemia. / Napoli, Claudio; Lerman, Lilach O.

In: Mayo Clinic Proceedings, Vol. 76, No. 6, 2001, p. 619-631.

Research output: Contribution to journalArticle

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