Involvement of GABA(A) receptors in myoclonus

Rae R. Matsumoto, Daniel D. Truong, Kevin D. Nguyen, A. Terri Dang, Tin T. Hoang, Phi Q. Vo, Paola Sandroni

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Alterations in multiple neurochemical systems have been reported in animal and human studies of posthypoxic myoclonus. It is impossible, however, to establish causative relationships between the observed changes and the myoclonic movements from these studies. Therefore, to establish causative links between neurochemical changes and myoclonus, ligands that target neurotransmitter systems that are altered in posthypoxic myoclonus were microinjected into the lateral ventricles of normal rats to identify the changes that can produce myoclonus. Of the ligands that were tested, only the GABA(A) antagonists produced myoclonus after intracerebroventricular administration, suggesting the importance of disinhibition of GABAergic systems in myoclonus. To further examine the role of GABA in myoclonus, GABAergic antagonists were microinjected into the nucleus reticularis of the thalamus (NRT), an area of the brain in which extensive pathologic changes are seen in posthypoxic animals. GABA(A), but not GABA(B), antagonists produced myoclonus after microinjection into the NRT. Earlier investigators have further reported the ability of GABA(A) antagonists to produce myoclonus after microinjection into the caudate. The data therefore suggest that disruption of activity at GABA(A) receptors at any one of a number of levels in the neural axis can produce myoclonus.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalMovement Disorders
Volume15
Issue numberSUPPL. 1
StatePublished - Apr 4 2000

Keywords

  • Caudate
  • Cortex
  • GABA
  • Myoclonus
  • Nucleus reticularis thalami

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Matsumoto, R. R., Truong, D. D., Nguyen, K. D., Dang, A. T., Hoang, T. T., Vo, P. Q., & Sandroni, P. (2000). Involvement of GABA(A) receptors in myoclonus. Movement Disorders, 15(SUPPL. 1), 47-52.