Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD

Y. Inamoto, M. Jagasia, W. A. Wood, J. Pidala, Jeanne Palmer, Nandita D Khera, D. Weisdorf, P. A. Carpenter, M. E D Flowers, D. Jacobsohn, P. J. Martin, S. J. Lee, S. Z. Pavletic

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The 2005 National Institutes of Health (NIH) consensus criteria for chronic GVHD have set standards for reporting. Many questions, however, have arisen regarding their implementation and utilization. To identify perceived areas of controversy, we conducted an international survey on diagnosis and scoring of chronic GVHD. Agreement was observed for 50-83% of the 72 questions in 7 topic areas. There was agreement on the need for modifying criteria in six situations: two or more distinctive manifestations should be enough to diagnose chronic GVHD; symptoms that are not due to chronic GVHD should be scored differently; active disease and fixed deficits should be distinguished; a minimum threshold body surface area of hidebound skin involvement should be required for a skin score of 3; asymptomatic oral lichenoid changes should be considered a score 1; and lung biopsy should be unnecessary to diagnose chronic GVHD in a patient with bronchiolitis obliterans as the only manifestation. The survey also identified 26 points of controversy. Whenever possible, studies should be conducted to confirm the appropriateness of any revisions. In cases where data are not available, clarification of the NIH recommendations by consensus is necessary. This survey should inform future research in the field and revisions of the current consensus criteria.

Original languageEnglish (US)
Pages (from-to)532-538
Number of pages7
JournalBone Marrow Transplantation
Volume49
Issue number4
DOIs
StatePublished - 2014

Fingerprint

National Institutes of Health (U.S.)
Research Personnel
Bronchiolitis Obliterans
Skin
Body Surface Area
Biopsy
Lung
Surveys and Questionnaires

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Chronic GVHD
  • Consensus
  • Controversy
  • National Institutes of Health

ASJC Scopus subject areas

  • Hematology
  • Transplantation
  • Medicine(all)

Cite this

Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD. / Inamoto, Y.; Jagasia, M.; Wood, W. A.; Pidala, J.; Palmer, Jeanne; Khera, Nandita D; Weisdorf, D.; Carpenter, P. A.; Flowers, M. E D; Jacobsohn, D.; Martin, P. J.; Lee, S. J.; Pavletic, S. Z.

In: Bone Marrow Transplantation, Vol. 49, No. 4, 2014, p. 532-538.

Research output: Contribution to journalArticle

Inamoto, Y, Jagasia, M, Wood, WA, Pidala, J, Palmer, J, Khera, ND, Weisdorf, D, Carpenter, PA, Flowers, MED, Jacobsohn, D, Martin, PJ, Lee, SJ & Pavletic, SZ 2014, 'Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD', Bone Marrow Transplantation, vol. 49, no. 4, pp. 532-538. https://doi.org/10.1038/bmt.2013.225
Inamoto, Y. ; Jagasia, M. ; Wood, W. A. ; Pidala, J. ; Palmer, Jeanne ; Khera, Nandita D ; Weisdorf, D. ; Carpenter, P. A. ; Flowers, M. E D ; Jacobsohn, D. ; Martin, P. J. ; Lee, S. J. ; Pavletic, S. Z. / Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD. In: Bone Marrow Transplantation. 2014 ; Vol. 49, No. 4. pp. 532-538.
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