Investigating the Metabolic Syndrome

Xin Zhang, Lilach O Lerman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The metabolic syndrome (MetS), a cluster of dyslipidemia, hypertension, and diabetes and an important contributor to cardiovascular morbidity and mortality, occurs in nearly 35% of adults and 50% of the aging population in the United States. However, the underlying mechanisms by which MetS orchestrates and amplifies cardiovascular events remain elusive. Furthermore, traditional therapeutic strategies addressing lifestyle modifications and individual components of MetS are often unsuccessful in decreasing morbidity due to MetS. The availability of an adequate experimental platform that mimics the complexity of MetS may allow development of novel management techniques. Swine models, including domestic pigs and minipigs, have made important contributions to our understanding of many aspects of MetS. Given their similarity to human anatomy and physiology, those models may have significant predictive power for elucidating the pathophysiology of MetS in a manner applicable to humans. Moreover, experimental maneuvers and drugs can be tested in these preclinical models before application in patients with MetS. This review highlights the utility of the pig as an animal model for metabolic disorders, which may play a crucial role in novel drug development to optimize management of MetS.

Original languageEnglish (US)
Pages (from-to)358-366
Number of pages9
JournalToxicologic Pathology
Volume44
Issue number3
DOIs
StatePublished - Apr 1 2016

Fingerprint

Physiology
Medical problems
Pharmaceutical Preparations
Animals
Aging of materials
Availability
Swine
Morbidity
Miniature Swine
Sus scrofa
Dyslipidemias
Life Style
Anatomy
Animal Models
Hypertension
Mortality
Population
Therapeutics

Keywords

  • adiposity
  • hypertension
  • insulin resistance
  • metabolic syndrome
  • swine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

Investigating the Metabolic Syndrome. / Zhang, Xin; Lerman, Lilach O.

In: Toxicologic Pathology, Vol. 44, No. 3, 01.04.2016, p. 358-366.

Research output: Contribution to journalArticle

Zhang, Xin ; Lerman, Lilach O. / Investigating the Metabolic Syndrome. In: Toxicologic Pathology. 2016 ; Vol. 44, No. 3. pp. 358-366.
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