Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality

Ajoy Dias; Aref Al-Kali; Daniel Van Dyke; Dietger Niederwieser; Vladan Vucinic; Johannes Lemke; Christel Muller; Sebastian Schwind; Anne Christin Teichmann; Ruth Bakken; Linda J. Burns; Mark Litzow

doi:10.1016/j.bbmt.2017.05.019

Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality

Ajoy Dias, Aref Al-Kali, Daniel Van Dyke, Dietger Niederwieser, Vladan Vucinic, Johannes Lemke, Christel Muller, Sebastian Schwind, Anne Christin Teichmann, Ruth Bakken, Linda J. Burns, Mark Litzow

Research output: Contribution to journal › Article › peer-review

Abstract

Allogeneic hematopoietic cell transplantation (HCT) is an important treatment for many severe hematologic disorders; however, HCT can be associated with significant complications, including organ toxicity, graft-versus-host disease, and relapse. Another serious, but rare, complication is the transmission of hematologic and nonhematologic diseases from the donor to the recipient. With older donors, the risk of an abnormality may be increased. Here we describe the transmission of an inversion 3 constitutional cytogenetic abnormality from an unrelated donor to a recipient, and review the clinical implications of the discovery of donor-derived constitutional cytogenetic abnormalities.

Original language	English (US)
Pages (from-to)	1582-1587
Number of pages	6
Journal	Biology of Blood and Marrow Transplantation
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2017.05.019
State	Published - Sep 2017

Keywords

Acute myelogenous leukemia
Allogeneic hematopoietic cell transplantation
Cytogenetics
Karyotype
inv (3)

ASJC Scopus subject areas

Hematology
Transplantation

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10.1016/j.bbmt.2017.05.019

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Dias, A., Al-Kali, A., Van Dyke, D., Niederwieser, D., Vucinic, V., Lemke, J., Muller, C., Schwind, S., Teichmann, A. C., Bakken, R., Burns, L. J., & Litzow, M. (2017). Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality. Biology of Blood and Marrow Transplantation, 23(9), 1582-1587. https://doi.org/10.1016/j.bbmt.2017.05.019

Dias, A, Al-Kali, A, Van Dyke, D, Niederwieser, D, Vucinic, V, Lemke, J, Muller, C, Schwind, S, Teichmann, AC, Bakken, R, Burns, LJ & Litzow, M 2017, 'Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality', Biology of Blood and Marrow Transplantation, vol. 23, no. 9, pp. 1582-1587. https://doi.org/10.1016/j.bbmt.2017.05.019

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abstract = "Allogeneic hematopoietic cell transplantation (HCT) is an important treatment for many severe hematologic disorders; however, HCT can be associated with significant complications, including organ toxicity, graft-versus-host disease, and relapse. Another serious, but rare, complication is the transmission of hematologic and nonhematologic diseases from the donor to the recipient. With older donors, the risk of an abnormality may be increased. Here we describe the transmission of an inversion 3 constitutional cytogenetic abnormality from an unrelated donor to a recipient, and review the clinical implications of the discovery of donor-derived constitutional cytogenetic abnormalities.",

keywords = "Acute myelogenous leukemia, Allogeneic hematopoietic cell transplantation, Cytogenetics, Karyotype, inv (3)",

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doi = "10.1016/j.bbmt.2017.05.019",

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AU - Al-Kali, Aref

AU - Van Dyke, Daniel

AU - Niederwieser, Dietger

AU - Vucinic, Vladan

AU - Lemke, Johannes

AU - Muller, Christel

AU - Schwind, Sebastian

AU - Teichmann, Anne Christin

AU - Bakken, Ruth

AU - Burns, Linda J.

AU - Litzow, Mark

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AB - Allogeneic hematopoietic cell transplantation (HCT) is an important treatment for many severe hematologic disorders; however, HCT can be associated with significant complications, including organ toxicity, graft-versus-host disease, and relapse. Another serious, but rare, complication is the transmission of hematologic and nonhematologic diseases from the donor to the recipient. With older donors, the risk of an abnormality may be increased. Here we describe the transmission of an inversion 3 constitutional cytogenetic abnormality from an unrelated donor to a recipient, and review the clinical implications of the discovery of donor-derived constitutional cytogenetic abnormalities.

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KW - Cytogenetics

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Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality

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Keywords

ASJC Scopus subject areas

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