Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor-Derived Constitutional Abnormality

Ajoy Dias, Aref Al-Kali, Daniel Van Dyke, Dietger Niederwieser, Vladan Vucinic, Johannes Lemke, Christel Muller, Sebastian Schwind, Anne Christin Teichmann, Ruth Bakken, Linda J. Burns, Mark Litzow

Research output: Contribution to journalArticlepeer-review

Abstract

Allogeneic hematopoietic cell transplantation (HCT) is an important treatment for many severe hematologic disorders; however, HCT can be associated with significant complications, including organ toxicity, graft-versus-host disease, and relapse. Another serious, but rare, complication is the transmission of hematologic and nonhematologic diseases from the donor to the recipient. With older donors, the risk of an abnormality may be increased. Here we describe the transmission of an inversion 3 constitutional cytogenetic abnormality from an unrelated donor to a recipient, and review the clinical implications of the discovery of donor-derived constitutional cytogenetic abnormalities.

Original languageEnglish (US)
Pages (from-to)1582-1587
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • Acute myelogenous leukemia
  • Allogeneic hematopoietic cell transplantation
  • Cytogenetics
  • Karyotype
  • inv (3)

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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