Intravitreal Toxicity of Hydroxyacyclovir (bw-b759u), a New Antiviral Agent

Jose Pulido, Gholam A. Peyman, Timothy Lesar, Jackie Vernot

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

We investigated the toxicity of the antiviral compound hydroxyacyclovir (9-[hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or BW-B759U), following intravitreal injection in the rabbit. Intravitreal doses of 10, 20, 40, 80, 100, 200, and 400 μg produced no discernible ophthalmoscopic or histologic changes. Intravitreal doses of 40, 200, and 400 μg produced no changes in the electroretinography B-waves. The low level of retinal toxicity and excellent median inhibitory dose values of intravitreal BW-B759U against cytomegalovirus suggest its potential therapeutic utility in the treatment of cytomegalovirus retinitis.

Original languageEnglish (US)
Pages (from-to)840-841
Number of pages2
JournalArchives of ophthalmology
Volume103
Issue number6
DOIs
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Ophthalmology

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