TY - JOUR
T1 - Intravitreal Toxicity of Hydroxyacyclovir (bw-b759u), a New Antiviral Agent
AU - Pulido, Jose
AU - Peyman, Gholam A.
AU - Lesar, Timothy
AU - Vernot, Jackie
PY - 1985/6
Y1 - 1985/6
N2 - We investigated the toxicity of the antiviral compound hydroxyacyclovir (9-[hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or BW-B759U), following intravitreal injection in the rabbit. Intravitreal doses of 10, 20, 40, 80, 100, 200, and 400 μg produced no discernible ophthalmoscopic or histologic changes. Intravitreal doses of 40, 200, and 400 μg produced no changes in the electroretinography B-waves. The low level of retinal toxicity and excellent median inhibitory dose values of intravitreal BW-B759U against cytomegalovirus suggest its potential therapeutic utility in the treatment of cytomegalovirus retinitis.
AB - We investigated the toxicity of the antiviral compound hydroxyacyclovir (9-[hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or BW-B759U), following intravitreal injection in the rabbit. Intravitreal doses of 10, 20, 40, 80, 100, 200, and 400 μg produced no discernible ophthalmoscopic or histologic changes. Intravitreal doses of 40, 200, and 400 μg produced no changes in the electroretinography B-waves. The low level of retinal toxicity and excellent median inhibitory dose values of intravitreal BW-B759U against cytomegalovirus suggest its potential therapeutic utility in the treatment of cytomegalovirus retinitis.
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U2 - 10.1001/archopht.1985.01050060100036
DO - 10.1001/archopht.1985.01050060100036
M3 - Article
C2 - 3873931
AN - SCOPUS:0021888024
SN - 0003-9950
VL - 103
SP - 840
EP - 841
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -