Intravitreal Bevacizumab (Avastin) Injection in Ocular Ischemic Syndrome

Luis Amselem, Javier Montero, Manuel Diaz-Llopis, Jose S. Pulido, Sophie J. Bakri, Paula Palomares, Salvador Garcia-Delpech

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Abstract

Purpose: To determine whether bevacizumab may improve anatomic and visual outcomes in patients with ocular ischemic syndrome (OIS). Design: Interventional case reports. Methods: Two patients with OIS presenting with unilateral ocular pain, iris neovascularization, and macular edema. Intravitreal injection of bevacizumab (1.25 mg). The main outcome measures were postinjection best-corrected visual acuity (BCVA), intraocular pressure (IOP), angiographic findings, and optical coherence tomography (OCT) findings and complications. Results: One week after treatment, both patients demonstrated regression of the iris neovascularization and improvement of the macular edema, with no changes in BCVA and IOP. One eye was reinjected at four months. After three and seven months, no significant or systemic adverse events were observed, and no signs of new iris neovascularization were present. Conclusions: Intravitreal bevacizumab may be useful for the treatment of eyes with iris neovascularization and macular edema secondary to OIS.

Original languageEnglish (US)
Pages (from-to)122-124
Number of pages3
JournalAmerican journal of ophthalmology
Volume144
Issue number1
DOIs
StatePublished - Jul 1 2007

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Amselem, L., Montero, J., Diaz-Llopis, M., Pulido, J. S., Bakri, S. J., Palomares, P., & Garcia-Delpech, S. (2007). Intravitreal Bevacizumab (Avastin) Injection in Ocular Ischemic Syndrome. American journal of ophthalmology, 144(1), 122-124. https://doi.org/10.1016/j.ajo.2007.02.037