Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Michael Puumala; Robert E. Anderson; Fredric B. Meyer

doi:10.1016/0006-8993(90)90140-7

Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Michael Puumala, Robert E. Anderson, Fredric B. Meyer

Neurosurgery

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

Original language	English (US)
Pages (from-to)	283-286
Number of pages	4
Journal	Brain Research
Volume	534
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(90)90140-7
State	Published - Nov 26 1990

Keywords

Angiogenesis
Capillary
Cerebral
Growth factor
Ischemia

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(90)90140-7

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title = "Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat",

abstract = "The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.",

keywords = "Angiogenesis, Capillary, Cerebral, Growth factor, Ischemia",

author = "Michael Puumala and Anderson, {Robert E.} and Meyer, {Fredric B.}",

note = "Funding Information: This work was supported by NIH 25374-02 and a faculty research grant from the American Association of Neurological Surgeons.",

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T1 - Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

AU - Puumala, Michael

AU - Anderson, Robert E.

AU - Meyer, Fredric B.

N1 - Funding Information: This work was supported by NIH 25374-02 and a faculty research grant from the American Association of Neurological Surgeons.

PY - 1990/11/26

Y1 - 1990/11/26

N2 - The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

AB - The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

KW - Angiogenesis

KW - Capillary

KW - Cerebral

KW - Growth factor

KW - Ischemia

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Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Abstract

Keywords

ASJC Scopus subject areas

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