Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Michael Puumala, Robert E. Anderson, Fredric B. Meyer

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalBrain Research
Volume534
Issue number1-2
DOIs
StatePublished - Nov 26 1990
Externally publishedYes

Fingerprint

Intraventricular Infusions
Fibroblast Growth Factor 2
Wistar Rats
Intercellular Signaling Peptides and Proteins
Cerebral Cortex
Brain
In Vitro Techniques

Keywords

  • Angiogenesis
  • Capillary
  • Cerebral
  • Growth factor
  • Ischemia

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat. / Puumala, Michael; Anderson, Robert E.; Meyer, Fredric B.

In: Brain Research, Vol. 534, No. 1-2, 26.11.1990, p. 283-286.

Research output: Contribution to journalArticle

Puumala, Michael ; Anderson, Robert E. ; Meyer, Fredric B. / Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat. In: Brain Research. 1990 ; Vol. 534, No. 1-2. pp. 283-286.
@article{9c380f5ee6f7448ebbb528d828c520ce,
title = "Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat",
abstract = "The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.",
keywords = "Angiogenesis, Capillary, Cerebral, Growth factor, Ischemia",
author = "Michael Puumala and Anderson, {Robert E.} and Meyer, {Fredric B.}",
year = "1990",
month = "11",
day = "26",
doi = "10.1016/0006-8993(90)90140-7",
language = "English (US)",
volume = "534",
pages = "283--286",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

AU - Puumala, Michael

AU - Anderson, Robert E.

AU - Meyer, Fredric B.

PY - 1990/11/26

Y1 - 1990/11/26

N2 - The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

AB - The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

KW - Angiogenesis

KW - Capillary

KW - Cerebral

KW - Growth factor

KW - Ischemia

UR - http://www.scopus.com/inward/record.url?scp=0025223671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025223671&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(90)90140-7

DO - 10.1016/0006-8993(90)90140-7

M3 - Article

C2 - 1705852

AN - SCOPUS:0025223671

VL - 534

SP - 283

EP - 286

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -