Intraocular use of rituximab

A. S. Kitzmann, J. S. Pulido, B. G. Mohney, K. H. Baratz, T. Grube, R. J. Marler, M. J. Donaldson, B. P. O'Neill, P. B. Johnston, K. M. Johnson, L. E. Dixon, D. R. Salomao, J. D. Cameron

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Purpose: To evaluate the toxicity of 1 mg of intraocular rituximab and to present a small case-series of patients treated with intravitreal rituximab. Methods: Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits. Two animals were injected with balanced salt solution as controls. At 1 month the rabbits were killed and the eyes examined by light microscopy. Three patients (five eyes) with intraocular lymphoma were also treated with a 1 mg injection of rituximab. Results: The treated rabbit eyes and the control eyes showed no light microscopic evidence of ocular toxicity at 1 month following injection. The five human eyes of three patients have shown no evidence of intraocular toxicity with a median follow-up time of 3.6 months (range 2.0-6.4 months). One patient received a total of four injections in the right eye and three injections in the left eye. Conclusion: Intravitreal rituximab at a dose of 1 mg does not appear to cause toxicity in rabbit eyes and in the five eyes of three patients.

Original languageEnglish (US)
Pages (from-to)1524-1527
Number of pages4
JournalEye
Volume21
Issue number12
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K. H., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R., & Cameron, J. D. (2007). Intraocular use of rituximab. Eye, 21(12), 1524-1527. https://doi.org/10.1038/sj.eye.6702804