Intracranial metastasis in fibrolamellar hepatocellular carcinoma

William J. Hammond, Gadi Lalazar, James A. Saltsman, Benjamin A. Farber, Enrico Danzer, Tshering C. Sherpa, Charles D. Banda, Jeffrey R. Andolina, Sasan Karimi, Cameron W. Brennan, Michael Torbenson, Michael P. La Quaglia, Sanford M. Simon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.

Original languageEnglish (US)
Article numbere26919
JournalPediatric Blood and Cancer
Volume65
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Neoplasm Metastasis
Young Adult
Brain
Neuroimaging
Neoplasms
Histology
Pediatrics
Recurrence
Liver
Population
Fibrolamellar hepatocellular carcinoma
Therapeutics

Keywords

  • adolescent and young adult tumors
  • brain
  • fibrolamellar
  • liver
  • rare tumors
  • tumor biology
  • tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Hammond, W. J., Lalazar, G., Saltsman, J. A., Farber, B. A., Danzer, E., Sherpa, T. C., ... Simon, S. M. (2018). Intracranial metastasis in fibrolamellar hepatocellular carcinoma. Pediatric Blood and Cancer, 65(4), [e26919]. https://doi.org/10.1002/pbc.26919

Intracranial metastasis in fibrolamellar hepatocellular carcinoma. / Hammond, William J.; Lalazar, Gadi; Saltsman, James A.; Farber, Benjamin A.; Danzer, Enrico; Sherpa, Tshering C.; Banda, Charles D.; Andolina, Jeffrey R.; Karimi, Sasan; Brennan, Cameron W.; Torbenson, Michael; La Quaglia, Michael P.; Simon, Sanford M.

In: Pediatric Blood and Cancer, Vol. 65, No. 4, e26919, 01.04.2018.

Research output: Contribution to journalArticle

Hammond, WJ, Lalazar, G, Saltsman, JA, Farber, BA, Danzer, E, Sherpa, TC, Banda, CD, Andolina, JR, Karimi, S, Brennan, CW, Torbenson, M, La Quaglia, MP & Simon, SM 2018, 'Intracranial metastasis in fibrolamellar hepatocellular carcinoma', Pediatric Blood and Cancer, vol. 65, no. 4, e26919. https://doi.org/10.1002/pbc.26919
Hammond WJ, Lalazar G, Saltsman JA, Farber BA, Danzer E, Sherpa TC et al. Intracranial metastasis in fibrolamellar hepatocellular carcinoma. Pediatric Blood and Cancer. 2018 Apr 1;65(4). e26919. https://doi.org/10.1002/pbc.26919
Hammond, William J. ; Lalazar, Gadi ; Saltsman, James A. ; Farber, Benjamin A. ; Danzer, Enrico ; Sherpa, Tshering C. ; Banda, Charles D. ; Andolina, Jeffrey R. ; Karimi, Sasan ; Brennan, Cameron W. ; Torbenson, Michael ; La Quaglia, Michael P. ; Simon, Sanford M. / Intracranial metastasis in fibrolamellar hepatocellular carcinoma. In: Pediatric Blood and Cancer. 2018 ; Vol. 65, No. 4.
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