Intra -H-2 recombination in the mouse - III. I-region characterization of haplotypes H-2at2, H-2at3 and H-2a2

Kirk W. Beisel, Howard C. Passmore, Chella S. David

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Abstract

Serological characterization of three K-S interval recombinant strains, TBR2 (H-2at2), TBR3 (H-2at3) and AIR1 (H-2a2) was performed using anti-H-2, Ia, Ss and Slp antisera. The data presented here reveal that the crossover events in both TBR2 and TBR3 occurred between the I-A and I-E subregions. In both cases, the H-2K and I-A subregions were derived from the H-2t1 chromosome, while the I-E, S and H-2D regions were derived from the H-2b chromosome (KsAkEbSbDb). The H-2a2 chromosome resulted from a crossover event between the H-2a1 and H-2i9 chromosomes. Ia and Ss typing of AIR1 suggested that the K to I-E regions originated from H-2a1 and the S and D regions originated from H-2i9 (KkAkEkSbDd).

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalImmunogenetics
Volume11
Issue number1
DOIs
StatePublished - Dec 1 1980

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ASJC Scopus subject areas

  • Immunology
  • Genetics

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