Intra -H-2 recombination in the mouse - III. I-region characterization of haplotypes H-2^at2, H-2^at3 and H-2^a2

Serological characterization of three K-S interval recombinant strains, TBR2 (H-2^at2), TBR3 (H-2^at3) and AIR1 (H-2^a2) was performed using anti-H-2, Ia, Ss and Slp antisera. The data presented here reveal that the crossover events in both TBR2 and TBR3 occurred between the I-A and I-E subregions. In both cases, the H-2K and I-A subregions were derived from the H-2^t1 chromosome, while the I-E, S and H-2D regions were derived from the H-2^b chromosome (K^sA^kE^bS^bD^b). The H-2^a2 chromosome resulted from a crossover event between the H-2^a1 and H-2ⁱ⁹ chromosomes. Ia and Ss typing of AIR1 suggested that the K to I-E regions originated from H-2^a1 and the S and D regions originated from H-2ⁱ⁹ (K^kA^kE^kS^bD^d).