Abstract
Although diarrhea is the predominant bowel dysfunction in as many as one-third of patients with irritable bowel syndrome (IBS), it is unclear whether there is a specific disorder of intestinal fluid or electrolyte secretion in IBS. Diarrhea is generally considered a result of accelerated colonic transit in patients with IBS. Although a primary secretory diathesis has not been well-documented in patients with IBS with diarrhea (IBS-D), several mechanisms that could potentially contribute to intestinal secretion have been reported. Some of these mechanisms also influence motor and secretory dysfunctions that contribute to the pathophysiology of IBS-D. We review the evidence supporting secretion in IBS-D caused by peptides and amines produced by enteroendocrine cells or submucosal neurons, enterocyte secretory processes, and intraluminal factors (bile acids and short-chain fatty acids). Understanding these mechanisms and developing clinical methods for their identification could improve management of patients with IBS-D.
Original language | English (US) |
---|---|
Pages (from-to) | 1051-1057 |
Number of pages | 7 |
Journal | Clinical Gastroenterology and Hepatology |
Volume | 13 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2015 |
Keywords
- Absorption
- Intestine
- Pathogenesis
- SCFA
ASJC Scopus subject areas
- Hepatology
- Gastroenterology