Intestinal microbiota, pathophysiology and translation to probiotic use in patients with irritable bowel syndrome

Cristina Almansa, Anurag Agrawal, Lesley A. Houghton

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Probiotic agents have received growing attention in recent years as an alternative therapeutic tool in the management of irritable bowel syndrome. In this article, we will discuss the rationale that support this indication, including the role of intestinal microbiota in gastrointestinal function in both human and animal models, potential links between an impaired microbiota imbalance and the psycho-immunopathophysiology of irritable bowel syndrome, and the results of the available clinical trials to date.

Original languageEnglish (US)
Pages (from-to)383-398
Number of pages16
JournalExpert Review of Gastroenterology and Hepatology
Volume6
Issue number3
StatePublished - Jun 2012

Keywords

  • immune system
  • inflammation
  • irritable bowel syndrome
  • motility
  • probiotics
  • visceral sensitivity

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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