TY - JOUR
T1 - Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude
AU - Taylor, Bryan J.
AU - Stewart, Glenn M.
AU - Marck, Jan W.
AU - Summerfield, Douglas T.
AU - Issa, Amine N.
AU - Johnson, Bruce D.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/9
Y1 - 2017/9
N2 - We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 (12 ± 8%), and Day 9 (17 ± 11%) (all P ≤ 0.001) at EBC. There was no change in ULCs from sea-level to Day 1, Day 5 and Day 9 at EBC. These data provide evidence that interstitial lung fluid remains stable or may even decrease relative to at sea-level following 8 days of gradual exposure to high-altitude in healthy humans.
AB - We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 (12 ± 8%), and Day 9 (17 ± 11%) (all P ≤ 0.001) at EBC. There was no change in ULCs from sea-level to Day 1, Day 5 and Day 9 at EBC. These data provide evidence that interstitial lung fluid remains stable or may even decrease relative to at sea-level following 8 days of gradual exposure to high-altitude in healthy humans.
KW - High-altitude pulmonary oedema
KW - Hypoxia
KW - Lung diffusing capacity
KW - Ultrasound lung comets
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U2 - 10.1016/j.resp.2017.05.010
DO - 10.1016/j.resp.2017.05.010
M3 - Article
C2 - 28554819
AN - SCOPUS:85020295620
SN - 1569-9048
VL - 243
SP - 77
EP - 85
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -