Abstract
Implementation of network systems biology principles offers unparalleled opportunity to synthesize and integrate inherently complex high-throughput data for meaningful interpretation. Nonstochastic network templates constructed from extant knowledge facilitate large data set prioritization and prognostication, identifying context-dependent candidates for follow-up functional validation and interpretation. In conjunction, enrichment and representation assessment refines comprehension of network-associated molecular functions and biological processes. Together, exploiting intrinsic network properties provides a value-added decision-support instrument for data deconvolution in systems biomedicine.
Original language | English (US) |
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Pages (from-to) | 389-392 |
Number of pages | 4 |
Journal | Clinical pharmacology and therapeutics |
Volume | 93 |
Issue number | 5 |
DOIs | |
State | Published - May 2013 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)