Interplay between tight junctions & adherens junctions

Hannah K. Campbell, Jessica Maiers, Kris A. DeMali

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at sites of cell-cell contact are the adherens junctions and tight junctions. The adherens junctions mediate cell-cell adhesion via the actions of nectins and cadherins. The tight junctions regulate passage of ions and small molecules between cells and establish cell polarity. Historically, the adherens and tight junctions have been thought of as discrete complexes. However, it is now clear that a high level of interdependency exists between the two junctional complexes. The adherens junctions and tight junctions are physically linked, by the zonula occludens proteins, and linked via signaling molecules including several polarity complexes and actin cytoskeletal modifiers. This review will first describe the individual components of both the adherens and tight junctions and then discuss the coupling of the two complexes with an emphasis on the signaling links and physical interactions between the two junctional complexes.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalExperimental Cell Research
Volume358
Issue number1
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Adherens Junctions
Tight Junctions
Cell Adhesion
Zonula Occludens Proteins
Cell Polarity
Cadherins
Actins
Maintenance
Ions

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Interplay between tight junctions & adherens junctions. / Campbell, Hannah K.; Maiers, Jessica; DeMali, Kris A.

In: Experimental Cell Research, Vol. 358, No. 1, 01.09.2017, p. 39-44.

Research output: Contribution to journalReview article

Campbell, Hannah K. ; Maiers, Jessica ; DeMali, Kris A. / Interplay between tight junctions & adherens junctions. In: Experimental Cell Research. 2017 ; Vol. 358, No. 1. pp. 39-44.
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