TY - JOUR
T1 - Internet resources related to drug action and human response
T2 - A review
AU - Yao, L. X.
AU - Wu, Z. C.
AU - Ji, Z. L.
AU - Chen, Y. Z.
AU - Chen, X.
N1 - Funding Information:
This work is supported by the Zhejiang University Seed Grant 308200–243014 and the Ministry of Education Returned Scholar Seed Grant 2006–331.
Funding Information:
Information on the physical interactions involving drugs or their metabolites can also be retrieved from several bimolecular interaction databases that include protein-ligand interaction data, such as the Kinetic Data of Bimolecular Interactions site,[50] the Relibase site,[51] and the Bimolecular Interaction Network Database (BIND).[52] The BIND database currently represents the biggest effort to collect and organise biomolecular interaction data. The BIND database is maintained by the Blueprint Initiative, which is a research organisation funded by the Canadian government. It has assembled a large team of fully trained curators who constantly monitor molecular interaction information in recent publications, as well as back-fill interactions in older literature when time is available. So far, >190 000 interactions have been curated. BIND also develops tools for analysing the biomolecular interaction networks. For example, the BIND interaction viewer allows a user to generate customised pathways by expanding an interaction network at specified nodes. This function is particularly useful in the mechanistic study of known drug targets.
PY - 2006
Y1 - 2006
N2 - It has been demonstrated that numerous proteins interact with drugs or their metabolites. Knowledge of these proteins is necessary to understand the mechanisms of drug action and human response. Progress in modern genetics, molecular biology, biochemistry and pharmacology is generating a comprehensive mechanistic understanding of drug-target interaction on the molecular level. This is valuable for researchers and pharmaceutical companies in their efforts to improve the efficacy of existing drugs and to discover new ones. Most recently, the integration of a systems biology approach into drug discovery processes calls for more holistic knowledge and easily accessible resources of the proteins that are important in drug action and human response. We have reviewed many publicly accessible internet resources of these proteins, according to their roles in drug action and human response, such as therapeutic effect, adverse reaction, absorption, distribution, metabolism and excretion.
AB - It has been demonstrated that numerous proteins interact with drugs or their metabolites. Knowledge of these proteins is necessary to understand the mechanisms of drug action and human response. Progress in modern genetics, molecular biology, biochemistry and pharmacology is generating a comprehensive mechanistic understanding of drug-target interaction on the molecular level. This is valuable for researchers and pharmaceutical companies in their efforts to improve the efficacy of existing drugs and to discover new ones. Most recently, the integration of a systems biology approach into drug discovery processes calls for more holistic knowledge and easily accessible resources of the proteins that are important in drug action and human response. We have reviewed many publicly accessible internet resources of these proteins, according to their roles in drug action and human response, such as therapeutic effect, adverse reaction, absorption, distribution, metabolism and excretion.
UR - http://www.scopus.com/inward/record.url?scp=33747817947&partnerID=8YFLogxK
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U2 - 10.2165/00822942-200605030-00001
DO - 10.2165/00822942-200605030-00001
M3 - Review article
C2 - 16922594
AN - SCOPUS:33747817947
SN - 1175-5636
VL - 5
SP - 131
EP - 139
JO - Applied Bioinformatics
JF - Applied Bioinformatics
IS - 3
ER -