Internet resources related to drug action and human response: A review

L. X. Yao, Z. C. Wu, Z. L. Ji, Y. Z. Chen, X. Chen

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

It has been demonstrated that numerous proteins interact with drugs or their metabolites. Knowledge of these proteins is necessary to understand the mechanisms of drug action and human response. Progress in modern genetics, molecular biology, biochemistry and pharmacology is generating a comprehensive mechanistic understanding of drug-target interaction on the molecular level. This is valuable for researchers and pharmaceutical companies in their efforts to improve the efficacy of existing drugs and to discover new ones. Most recently, the integration of a systems biology approach into drug discovery processes calls for more holistic knowledge and easily accessible resources of the proteins that are important in drug action and human response. We have reviewed many publicly accessible internet resources of these proteins, according to their roles in drug action and human response, such as therapeutic effect, adverse reaction, absorption, distribution, metabolism and excretion.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalApplied Bioinformatics
Volume5
Issue number3
DOIs
StatePublished - Aug 31 2006

ASJC Scopus subject areas

  • Information Systems
  • Agricultural and Biological Sciences(all)
  • Computer Science Applications

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