International Prognostic Scoring System-independent cytogenetic risk categorization in primary myelofibrosis

Kebede Hussein, Animesh D Pardanani, Daniel L. Van Dyke, Curtis A. Hanson, Ayalew Tefferi

Research output: Contribution to journalArticle

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Abstract

Among 200 patients with primary myelofibrosis, karyotype at diagnosis was abnormal in 83 (42%). To assess their individual prognostic impact, specific cytogenetic abnormalities with more than or equal to 5 informative cases were identified and the rest grouped separately as "other abnormalities." Median survival in patients with sole +9 (n = 6), sole 20q-(n = 21), sole 13q- (n = 8), normal karyotype (n = 117), "other abnormalities" (n = 28), complex karyotype (n = 13), and sole +8 (n = 7) were "not reached," 112, 105, 80, 46, 34, and 28 months, respectively (P = .01). Accordingly, 4 cytogenetic risk groups were considered: (1) favorable (sole +9, 20q-, or 13q-), (2) normal, (3) unfavorable (complex karyotype or sole +8), and (4) "other abnormalities." Multivariable analysis confirmed the International Prognostic Scoring System (IPSS)-independent prognostic value of both 4-way and 2-way (ie, favorable/normal vs unfavorable/other abnormalities; IPSS-adjusted hazard ratio = 0.37; 95% confidence interval, 0.24-0.58) cytogenetic risk categorization (P < .01). The ability to prognostically dissect a specific IPSS category has major therapeutic implications.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalBlood
Volume115
Issue number3
DOIs
StatePublished - Jan 21 2010

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Primary Myelofibrosis
Karyotype
Cytogenetics
Hazards
Chromosome Aberrations
Confidence Intervals
Survival
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

International Prognostic Scoring System-independent cytogenetic risk categorization in primary myelofibrosis. / Hussein, Kebede; Pardanani, Animesh D; Van Dyke, Daniel L.; Hanson, Curtis A.; Tefferi, Ayalew.

In: Blood, Vol. 115, No. 3, 21.01.2010, p. 496-499.

Research output: Contribution to journalArticle

Hussein, Kebede ; Pardanani, Animesh D ; Van Dyke, Daniel L. ; Hanson, Curtis A. ; Tefferi, Ayalew. / International Prognostic Scoring System-independent cytogenetic risk categorization in primary myelofibrosis. In: Blood. 2010 ; Vol. 115, No. 3. pp. 496-499.
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