International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines

H. Tissot-Dupont, J. P. Casalta, F. Gouriet, S. Hubert, E. Salaun, G. Habib, M. P. Fernandez-Gerlinger, J. L. Mainardi, P. Tattevin, M. Revest, F. Lucht, E. Botelho-Nevers, A. Gagneux-Brunon, U. Snygg-Martin, K. L. Chan, J. Bishara, I. Vilacosta, C. Olmos, J. A. San Román, J. LópezP. Tornos, N. Fernández-Hidalgo, E. Durante-Mangoni, R. Utili, M. Paul, L. M. Baddour, D. C. De Simone, M. R. Sohail, J. M. Steckelberg, W. R. Wilson, D. Raoult

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centres. This is probably because most recommendations are not based on hard evidence, so the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed to evaluate this question in the particular field of antibiotic therapy. Methods: Thirteen international centres specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations. They were asked to detail their actual practice in terms of IE antibiotic treatment in various bacteriological and clinical situations. They were also asked to declare their IE-related in-hospital mortality for the year 2015. Results: The global compliance with guidelines concerning antibiotic therapy was 58%, revealing the differences between theoretical 'consensus', local recommendations and actual practice. Some conflicts of interest were also probably expressed. The adherence to guidelines was 100% when the protocol was simple, and decreased with the seriousness of the situation (Staphylococus spp. 54%-62%) or in blood-culture-negative endocarditis (0%-15%) that requires adaptation to clinical and epidemiological data. Conclusion: Worldwide experts in IE management, although the majority of them were involved and co-signed the guidelines, do not follow international consensus guidelines on the particular point of the use of antibiotics.

Original languageEnglish (US)
JournalClinical Microbiology and Infection
DOIs
StateAccepted/In press - Jun 29 2016

Fingerprint

Endocarditis
Guidelines
Anti-Bacterial Agents
Therapeutics
Guideline Adherence
Conflict of Interest
Hospital Mortality
Publications
Research

Keywords

  • Blood culture negative endocarditis
  • Endocarditis Treatment
  • Experts
  • Guidelines and practice
  • Staphylococcus aureus endocarditis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines. / Tissot-Dupont, H.; Casalta, J. P.; Gouriet, F.; Hubert, S.; Salaun, E.; Habib, G.; Fernandez-Gerlinger, M. P.; Mainardi, J. L.; Tattevin, P.; Revest, M.; Lucht, F.; Botelho-Nevers, E.; Gagneux-Brunon, A.; Snygg-Martin, U.; Chan, K. L.; Bishara, J.; Vilacosta, I.; Olmos, C.; San Román, J. A.; López, J.; Tornos, P.; Fernández-Hidalgo, N.; Durante-Mangoni, E.; Utili, R.; Paul, M.; Baddour, L. M.; De Simone, D. C.; Sohail, M. R.; Steckelberg, J. M.; Wilson, W. R.; Raoult, D.

In: Clinical Microbiology and Infection, 29.06.2016.

Research output: Contribution to journalArticle

Tissot-Dupont, H, Casalta, JP, Gouriet, F, Hubert, S, Salaun, E, Habib, G, Fernandez-Gerlinger, MP, Mainardi, JL, Tattevin, P, Revest, M, Lucht, F, Botelho-Nevers, E, Gagneux-Brunon, A, Snygg-Martin, U, Chan, KL, Bishara, J, Vilacosta, I, Olmos, C, San Román, JA, López, J, Tornos, P, Fernández-Hidalgo, N, Durante-Mangoni, E, Utili, R, Paul, M, Baddour, LM, De Simone, DC, Sohail, MR, Steckelberg, JM, Wilson, WR & Raoult, D 2016, 'International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines', Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2017.03.007
Tissot-Dupont, H. ; Casalta, J. P. ; Gouriet, F. ; Hubert, S. ; Salaun, E. ; Habib, G. ; Fernandez-Gerlinger, M. P. ; Mainardi, J. L. ; Tattevin, P. ; Revest, M. ; Lucht, F. ; Botelho-Nevers, E. ; Gagneux-Brunon, A. ; Snygg-Martin, U. ; Chan, K. L. ; Bishara, J. ; Vilacosta, I. ; Olmos, C. ; San Román, J. A. ; López, J. ; Tornos, P. ; Fernández-Hidalgo, N. ; Durante-Mangoni, E. ; Utili, R. ; Paul, M. ; Baddour, L. M. ; De Simone, D. C. ; Sohail, M. R. ; Steckelberg, J. M. ; Wilson, W. R. ; Raoult, D. / International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines. In: Clinical Microbiology and Infection. 2016.
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abstract = "Objective: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centres. This is probably because most recommendations are not based on hard evidence, so the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed to evaluate this question in the particular field of antibiotic therapy. Methods: Thirteen international centres specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations. They were asked to detail their actual practice in terms of IE antibiotic treatment in various bacteriological and clinical situations. They were also asked to declare their IE-related in-hospital mortality for the year 2015. Results: The global compliance with guidelines concerning antibiotic therapy was 58{\%}, revealing the differences between theoretical 'consensus', local recommendations and actual practice. Some conflicts of interest were also probably expressed. The adherence to guidelines was 100{\%} when the protocol was simple, and decreased with the seriousness of the situation (Staphylococus spp. 54{\%}-62{\%}) or in blood-culture-negative endocarditis (0{\%}-15{\%}) that requires adaptation to clinical and epidemiological data. Conclusion: Worldwide experts in IE management, although the majority of them were involved and co-signed the guidelines, do not follow international consensus guidelines on the particular point of the use of antibiotics.",
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T1 - International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines

AU - Tissot-Dupont, H.

AU - Casalta, J. P.

AU - Gouriet, F.

AU - Hubert, S.

AU - Salaun, E.

AU - Habib, G.

AU - Fernandez-Gerlinger, M. P.

AU - Mainardi, J. L.

AU - Tattevin, P.

AU - Revest, M.

AU - Lucht, F.

AU - Botelho-Nevers, E.

AU - Gagneux-Brunon, A.

AU - Snygg-Martin, U.

AU - Chan, K. L.

AU - Bishara, J.

AU - Vilacosta, I.

AU - Olmos, C.

AU - San Román, J. A.

AU - López, J.

AU - Tornos, P.

AU - Fernández-Hidalgo, N.

AU - Durante-Mangoni, E.

AU - Utili, R.

AU - Paul, M.

AU - Baddour, L. M.

AU - De Simone, D. C.

AU - Sohail, M. R.

AU - Steckelberg, J. M.

AU - Wilson, W. R.

AU - Raoult, D.

PY - 2016/6/29

Y1 - 2016/6/29

N2 - Objective: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centres. This is probably because most recommendations are not based on hard evidence, so the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed to evaluate this question in the particular field of antibiotic therapy. Methods: Thirteen international centres specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations. They were asked to detail their actual practice in terms of IE antibiotic treatment in various bacteriological and clinical situations. They were also asked to declare their IE-related in-hospital mortality for the year 2015. Results: The global compliance with guidelines concerning antibiotic therapy was 58%, revealing the differences between theoretical 'consensus', local recommendations and actual practice. Some conflicts of interest were also probably expressed. The adherence to guidelines was 100% when the protocol was simple, and decreased with the seriousness of the situation (Staphylococus spp. 54%-62%) or in blood-culture-negative endocarditis (0%-15%) that requires adaptation to clinical and epidemiological data. Conclusion: Worldwide experts in IE management, although the majority of them were involved and co-signed the guidelines, do not follow international consensus guidelines on the particular point of the use of antibiotics.

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KW - Blood culture negative endocarditis

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KW - Guidelines and practice

KW - Staphylococcus aureus endocarditis

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