International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Jelena Rima Ghadri; Ilan Shor Wittstein; Abhiram Prasad; Scott Sharkey; Keigo Dote; Yoshihiro John Akashi; Victoria Lucia Cammann; Filippo Crea; Leonarda Galiuto; Walter Desmet; Tetsuro Yoshida; Roberto Manfredini; Ingo Eitel; Masami Kosuge; Holger M. Nef; Abhishek Deshmukh; Amir Lerman; Eduardo Bossone; Rodolfo Citro; Takashi Ueyama; Domenico Corrado; Satoshi Kurisu; Frank Ruschitzka; David Winchester; Alexander R. Lyon; Elmir Omerovic; Jeroen J. Bax; Patrick Meimoun; Guiseppe Tarantini; Charanjit Rihal; Shams Y. Hassan; Federico Migliore; John D. Horowitz; Hiroaki Shimokawa; Thomas Felix Lüscher; Christian Templin

doi:10.1093/eurheartj/ehy076

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Jelena Rima Ghadri, Ilan Shor Wittstein, Abhiram Prasad, Scott Sharkey, Keigo Dote, Yoshihiro John Akashi, Victoria Lucia Cammann, Filippo Crea, Leonarda Galiuto, Walter Desmet, Tetsuro Yoshida, Roberto Manfredini, Ingo Eitel, Masami Kosuge, Holger M. Nef, Abhishek Deshmukh, Amir Lerman, Eduardo Bossone, Rodolfo Citro, Takashi UeyamaDomenico Corrado, Satoshi Kurisu, Frank Ruschitzka, David Winchester, Alexander R. Lyon, Elmir Omerovic, Jeroen J. Bax, Patrick Meimoun, Guiseppe Tarantini, Charanjit Rihal, Shams Y. Hassan, Federico Migliore, John D. Horowitz, Hiroaki Shimokawa, Thomas Felix Lüscher, Christian Templin

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

357 Scopus citations

Abstract

Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

Original language	English (US)
Pages (from-to)	2032-2046
Number of pages	15
Journal	European heart journal
Volume	39
Issue number	22
DOIs	https://doi.org/10.1093/eurheartj/ehy076
State	Published - Jun 7 2018

Keywords

Acute heart failure
Broken heart syndrome
Consensus statement
InterTAK Diagnostic Criteria
Takotsubo definition
Takotsubo syndrome

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1093/eurheartj/ehy076

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Ghadri, J. R., Wittstein, I. S., Prasad, A., Sharkey, S., Dote, K., Akashi, Y. J., Cammann, V. L., Crea, F., Galiuto, L., Desmet, W., Yoshida, T., Manfredini, R., Eitel, I., Kosuge, M., Nef, H. M., Deshmukh, A., Lerman, A., Bossone, E., Citro, R., ... Templin, C. (2018). International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. European heart journal, 39(22), 2032-2046. https://doi.org/10.1093/eurheartj/ehy076

Ghadri, JR, Wittstein, IS, Prasad, A, Sharkey, S, Dote, K, Akashi, YJ, Cammann, VL, Crea, F, Galiuto, L, Desmet, W, Yoshida, T, Manfredini, R, Eitel, I, Kosuge, M, Nef, HM, Deshmukh, A, Lerman, A, Bossone, E, Citro, R, Ueyama, T, Corrado, D, Kurisu, S, Ruschitzka, F, Winchester, D, Lyon, AR, Omerovic, E, Bax, JJ, Meimoun, P, Tarantini, G, Rihal, C, Hassan, SY, Migliore, F, Horowitz, JD, Shimokawa, H, Lüscher, TF & Templin, C 2018, 'International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology', European heart journal, vol. 39, no. 22, pp. 2032-2046. https://doi.org/10.1093/eurheartj/ehy076

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title = "International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology",

abstract = "Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.",

keywords = "Acute heart failure, Broken heart syndrome, Consensus statement, InterTAK Diagnostic Criteria, Takotsubo definition, Takotsubo syndrome",

author = "Ghadri, {Jelena Rima} and Wittstein, {Ilan Shor} and Abhiram Prasad and Scott Sharkey and Keigo Dote and Akashi, {Yoshihiro John} and Cammann, {Victoria Lucia} and Filippo Crea and Leonarda Galiuto and Walter Desmet and Tetsuro Yoshida and Roberto Manfredini and Ingo Eitel and Masami Kosuge and Nef, {Holger M.} and Abhishek Deshmukh and Amir Lerman and Eduardo Bossone and Rodolfo Citro and Takashi Ueyama and Domenico Corrado and Satoshi Kurisu and Frank Ruschitzka and David Winchester and Lyon, {Alexander R.} and Elmir Omerovic and Bax, {Jeroen J.} and Patrick Meimoun and Guiseppe Tarantini and Charanjit Rihal and Hassan, {Shams Y.} and Federico Migliore and Horowitz, {John D.} and Hiroaki Shimokawa and L{\"u}scher, {Thomas Felix} and Christian Templin",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2018",

month = jun,

day = "7",

doi = "10.1093/eurheartj/ehy076",

language = "English (US)",

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T2 - Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

AU - Ghadri, Jelena Rima

AU - Wittstein, Ilan Shor

AU - Prasad, Abhiram

AU - Sharkey, Scott

AU - Dote, Keigo

AU - Akashi, Yoshihiro John

AU - Cammann, Victoria Lucia

AU - Crea, Filippo

AU - Galiuto, Leonarda

AU - Desmet, Walter

AU - Yoshida, Tetsuro

AU - Manfredini, Roberto

AU - Eitel, Ingo

AU - Kosuge, Masami

AU - Nef, Holger M.

AU - Deshmukh, Abhishek

AU - Lerman, Amir

AU - Bossone, Eduardo

AU - Citro, Rodolfo

AU - Ueyama, Takashi

AU - Corrado, Domenico

AU - Kurisu, Satoshi

AU - Ruschitzka, Frank

AU - Winchester, David

AU - Lyon, Alexander R.

AU - Omerovic, Elmir

AU - Bax, Jeroen J.

AU - Meimoun, Patrick

AU - Tarantini, Guiseppe

AU - Rihal, Charanjit

AU - Hassan, Shams Y.

AU - Migliore, Federico

AU - Horowitz, John D.

AU - Shimokawa, Hiroaki

AU - Lüscher, Thomas Felix

AU - Templin, Christian

PY - 2018/6/7

Y1 - 2018/6/7

N2 - Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

AB - Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

KW - Acute heart failure

KW - Broken heart syndrome

KW - Consensus statement

KW - InterTAK Diagnostic Criteria

KW - Takotsubo definition

KW - Takotsubo syndrome

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JF - European heart journal

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ER -

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

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