Interleukin 4 promotes expression of mast cell ICAM-1 antigen

P. Valent; D. Bevec; D. Maurer; J. Besemer; F. Di Padova; J. H. Butterfield; W. Speiser; O. Majdic; K. Lechner; P. Bettelheim

doi:10.1073/pnas.88.8.3339

Interleukin 4 promotes expression of mast cell ICAM-1 antigen

P. Valent, D. Bevec, D. Maurer, J. Besemer, F. Di Padova, J. H. Butterfield, W. Speiser, O. Majdic, K. Lechner, P. Bettelheim

Allergic Diseases

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact- dependent regulation of immune cells in inflammed tissues.

Original language	English (US)
Pages (from-to)	3339-3342
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	8
DOIs	https://doi.org/10.1073/pnas.88.8.3339
State	Published - 1991

Keywords

cytokines
mast cells
recognition molecules

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.88.8.3339

Cite this

@article{0554254717694f60aa4c07515fb27163,

title = "Interleukin 4 promotes expression of mast cell ICAM-1 antigen",

abstract = "Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact- dependent regulation of immune cells in inflammed tissues.",

keywords = "cytokines, mast cells, recognition molecules",

author = "P. Valent and D. Bevec and D. Maurer and J. Besemer and {Di Padova}, F. and Butterfield, {J. H.} and W. Speiser and O. Majdic and K. Lechner and P. Bettelheim",

year = "1991",

doi = "10.1073/pnas.88.8.3339",

language = "English (US)",

volume = "88",

pages = "3339--3342",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "8",

}

TY - JOUR

T1 - Interleukin 4 promotes expression of mast cell ICAM-1 antigen

AU - Valent, P.

AU - Bevec, D.

AU - Maurer, D.

AU - Besemer, J.

AU - Di Padova, F.

AU - Butterfield, J. H.

AU - Speiser, W.

AU - Majdic, O.

AU - Lechner, K.

AU - Bettelheim, P.

PY - 1991

Y1 - 1991

N2 - Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact- dependent regulation of immune cells in inflammed tissues.

AB - Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact- dependent regulation of immune cells in inflammed tissues.

KW - cytokines

KW - mast cells

KW - recognition molecules

UR - http://www.scopus.com/inward/record.url?scp=0026326185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026326185&partnerID=8YFLogxK

U2 - 10.1073/pnas.88.8.3339

DO - 10.1073/pnas.88.8.3339

M3 - Article

C2 - 1673030

AN - SCOPUS:0026326185

SN - 0027-8424

VL - 88

SP - 3339

EP - 3342

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 8

ER -

Interleukin 4 promotes expression of mast cell ICAM-1 antigen

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this