Interleukin-4 may contribute to the abundant T-cell reaction and paucity of neoplastic B cells in T-cell-rich B-cell lymphomas

W. R. Macon, J. B. Cousar, J. A. Waldron, S. M. Hsu

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

T-cell-rich B-cell lymphomas (TCRBCLs) are diffuse lymphomas that contain a minority of large neoplastic B cells amidst a majority of non-neoplastic T cells and numerous histiocytes, an unusually pronounced reactive component not seen in most diffuse large B-cell lymphomas (DLBCLs). This reaction may be influenced by various cytokines secreted by lymphoma or reactive cells; therefore, expression of interleukin (IL) 1β, IL-2, IL-4, IL-6, and IL-9 was evaluated immunohistochemically on paraffin-embedded sections of 18 TCRBCLs and was compared with that of 15 DLBCLs containing a minority of reactive T cells and to that of seven reactive lymph nodes. Moderate to intense expression of IL-4 was detected in variable numbers of tumor cells and in numerous histiocytes in 16 TCRBCLs. In contrast, intense IL-4 expression in numerous histiocytes was observed in only one of 15 DLBCLs with few T cells. In four other DLBCLs and three reactive nodes, moderate to intense staining for IL-4 was noted only in rare large transformed cells or in occasional histiocytes. Except for one IL-1β positive and another IL-9 positive TCRBCL, there was no marking or weak staining only with other cytokine antibodies in the neoplastic and reactive cases studied. The expression of IL-4 in most TCRBCLs, but not in other DLBCLs or in reactive nodes, suggests that this cytokine is one factor involved in the pathobiology of the abundant T-cell reaction and, perhaps, contributes to the paucity of neoplastic B cells in TCRBCLs.

Original languageEnglish (US)
Pages (from-to)1031-1036
Number of pages6
JournalAmerican Journal of Pathology
Volume141
Issue number5
StatePublished - 1992
Externally publishedYes

Fingerprint

B-Cell Lymphoma
Interleukin-4
B-Lymphocytes
T-Lymphocytes
Lymphoma, Large B-Cell, Diffuse
Histiocytes
Interleukin-9
Cytokines
Interleukin-1
Staining and Labeling
Paraffin
Non-Hodgkin's Lymphoma
Interleukin-2
Interleukin-6
Lymphoma
Cell Count
Lymph Nodes
Antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Interleukin-4 may contribute to the abundant T-cell reaction and paucity of neoplastic B cells in T-cell-rich B-cell lymphomas. / Macon, W. R.; Cousar, J. B.; Waldron, J. A.; Hsu, S. M.

In: American Journal of Pathology, Vol. 141, No. 5, 1992, p. 1031-1036.

Research output: Contribution to journalArticle

Macon, W. R. ; Cousar, J. B. ; Waldron, J. A. ; Hsu, S. M. / Interleukin-4 may contribute to the abundant T-cell reaction and paucity of neoplastic B cells in T-cell-rich B-cell lymphomas. In: American Journal of Pathology. 1992 ; Vol. 141, No. 5. pp. 1031-1036.
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