Interleukin-2, cisplatin, and 5-fluorouracil for patients with non-small cell lung and head/neck carcinomas

Frank H. Valone, David R. Gandara, Albert B. Deisseroth, Edith A. Perez, Anthony Rayner, Frederick R. Aronson, Judith Luce, Carolyn Paradise

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24 Scopus citations

Abstract

The feasibility and efficacy of treating patients with locally recurrent or metastatic non-small cell lung cancer (NSCLC) or head/neck cancer with interleukin-2 (IL-2), cisplatin, and 5-fluorouracil (5-FU) was tested. Treatment was given every 28 days and consisted of cisplatin, 100 mg/m2 on days 1 and 8; 5-FU, 1,000 mg/m2 by continuous infusion on days 1-3; and IL-2, 12 million units/m2 by i.v. bolus on days 15-19. Thirty-four patients (22 NSCLC, 12 head/neck cancer) were registered in the study. The median age was 58 years; 59% had Karnofsky performance status of 70-80% and over one-half received prior therapy. All patients were evaluable for toxicity and 29 (18 NSCLC, 11 head/neck cancer) were evaluable for response. Twenty-five patients experienced at least one grade 3 or 4 toxicity, but these toxicities were transient and, in general, well tolerated. The response rate was 37% for NSCLC (0 complete response, 7 partial response) and 55% for head/neck cancer (2 complete response, 4 partial response). Two patients with head/neck cancer responded to treatment after failing prior therapy with cisplatin/5-FU alone. The combination of IL-2, cisplatin, and 5-FU is tolerable and active for treatment of NSCLC and head/neck carcinoma; the combination may not be cross-resistant with other chemotherapy combinations. Further studies of IL-2 combined with cisplatin/5-FU are warranted to determine the most effective dose and schedule.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalJournal of Immunotherapy
Volume10
Issue number3
DOIs
StatePublished - Jun 1991

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Keywords

  • 5-Fluorouracil
  • Cisplatin
  • Head/neck carcinoma
  • Interleukin-2
  • Non-small cell lung carcinoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

Cite this

Valone, F. H., Gandara, D. R., Deisseroth, A. B., Perez, E. A., Rayner, A., Aronson, F. R., Luce, J., & Paradise, C. (1991). Interleukin-2, cisplatin, and 5-fluorouracil for patients with non-small cell lung and head/neck carcinomas. Journal of Immunotherapy, 10(3), 207-213. https://doi.org/10.1097/00002371-199106000-00007