Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma

Aminah Jatoi, Phuong L. Nguyen, Nathan Foster, David Sun, Philip J. Stella, Megan Campbell, Loren K. Tschetter, Shaker R. Dakhil, James A. Mailliard, Daniel A. Nikcevich

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Interleukin-1 (IL-1) beta is a putative mediator of the cancer anorexia/ weight loss syndrome, and certain polymorphisms of its gene are thought to be associated with a greater risk of gastric cancer. Do these IL-1 beta genetic polymorphisms predispose patients with gastric and gastroesophageal cancer to the anorexia/weight loss syndrome? This study focused on 44 patients with metastatic gastric and gastroesophageal cancer. All underwent genotyping, completed serial quality-of-life questionnaires germane to appetite, and underwent meticulous serial follow-up. Patients with the IL-1 beta-31 C/7 and T/T genotypes were more likely to describe a worse appetite at baseline than were those with the C/C genotype. In addition, patients with the IL-1 beta+3954 C/T and T/T genotypes showed greater improvements in their weight (P = 0.02) and in survival (hazard ratio, 0.3; P = 0.04) over time than did patients with the C/C genotype. These associations occurred independently of tumor response. These preliminary data suggest that certain interleukin-1 beta genetic polymorphisms may modulate the cancer anorexia/weight loss syndrome in patients with metastatic gastric and esophageal cancer. Confirmatory studies are warranted.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalJournal of Supportive Oncology
Volume5
Issue number1
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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    Jatoi, A., Nguyen, P. L., Foster, N., Sun, D., Stella, P. J., Campbell, M., Tschetter, L. K., Dakhil, S. R., Mailliard, J. A., & Nikcevich, D. A. (2007). Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. Journal of Supportive Oncology, 5(1), 41-46.