Inter‐individual variation and cardioprotection in anthracycline‐induced heart failure

Nadine Norton, Raegan M. Weil, Pooja P. Advani

Research output: Contribution to journalReview articlepeer-review

Abstract

Anthracyclines are one of the most widely used and effective chemotherapies in oncology, but their most important side effect is the cumulative, dose‐related cardiotoxicity leading to congestive heart failure in ~5% of individuals. Methodology and pharmacogenetic studies for predicting which individuals are at high risk and subsequently the development of targeted and individualized cardioprotective plans are beginning to make progress. Here, we review current putative risk genes and variants, the strength of evidence for each genetic association and the interaction between risk genes, in the context of known clinical risk factors and potential novel cardioprotective strategies.

Original languageEnglish (US)
Article number4079
JournalJournal of Clinical Medicine
Volume10
Issue number18
DOIs
StatePublished - Sep 2021

Keywords

  • Adriamycin
  • Cardiomyopathy
  • Cardiotoxicity
  • CBR3
  • Chemotherapy
  • Doxorubicin
  • Pharmacogenetics
  • Risk variants
  • TRPC6

ASJC Scopus subject areas

  • Medicine(all)

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