Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore

Patricia S. Vaughan, Andre J van Wijnen, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the β-interferon gene and many interferon-stimulated genes. Two well studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-β gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

Original languageEnglish (US)
Pages (from-to)348-359
Number of pages12
JournalJournal of Molecular Medicine
Volume75
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Interferon Regulatory Factor-2
Interferon Regulatory Factors
Interferon Regulatory Factor-1
Histones
Interferons
Growth
Genes
Aptitude
Essential Genes
Cell Cycle

Keywords

  • cell cycle
  • histone
  • interferon
  • proliferation
  • transcription

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Interferon regulatory factors : Growth control and histone gene regulation - It's not just interferon anymore. / Vaughan, Patricia S.; van Wijnen, Andre J; Stein, Janet L.; Stein, Gary S.

In: Journal of Molecular Medicine, Vol. 75, No. 5, 1997, p. 348-359.

Research output: Contribution to journalArticle

Vaughan, Patricia S. ; van Wijnen, Andre J ; Stein, Janet L. ; Stein, Gary S. / Interferon regulatory factors : Growth control and histone gene regulation - It's not just interferon anymore. In: Journal of Molecular Medicine. 1997 ; Vol. 75, No. 5. pp. 348-359.
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