Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore

Patricia S. Vaughan; André J. Van Wijnen; Janet L. Stein; Gary S. Stein

doi:10.1007/s001090050120

Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore

Patricia S. Vaughan, André J. Van Wijnen, Janet L. Stein, Gary S. Stein

Orthopedic Surgery

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the β-interferon gene and many interferon-stimulated genes. Two well studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-β gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

Original language	English (US)
Pages (from-to)	348-359
Number of pages	12
Journal	Journal of Molecular Medicine
Volume	75
Issue number	5
DOIs	https://doi.org/10.1007/s001090050120
State	Published - 1997

Keywords

cell cycle
histone
interferon
proliferation
transcription

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

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10.1007/s001090050120

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title = "Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore",

abstract = "Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the β-interferon gene and many interferon-stimulated genes. Two well studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-β gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.",

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author = "Vaughan, {Patricia S.} and {Van Wijnen}, {Andr{\'e} J.} and Stein, {Janet L.} and Stein, {Gary S.}",

year = "1997",

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T2 - Growth control and histone gene regulation - It's not just interferon anymore

AU - Vaughan, Patricia S.

AU - Van Wijnen, André J.

AU - Stein, Janet L.

AU - Stein, Gary S.

PY - 1997

Y1 - 1997

N2 - Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the β-interferon gene and many interferon-stimulated genes. Two well studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-β gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

AB - Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the β-interferon gene and many interferon-stimulated genes. Two well studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-β gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

KW - cell cycle

KW - histone

KW - interferon

KW - proliferation

KW - transcription

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JO - Journal of Molecular Medicine

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IS - 5

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Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore

Abstract

Keywords

ASJC Scopus subject areas

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