Interdependence of blood pressure and heart period regulation in mild hypertension

A. J S Coats, J. Conway, P. Sleight, T. E. Meyer, Virend Somers, J. S. Floras, J. V. Jones

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pressure varies over a range of approximately 40% around the mean by day and by approximately 20% at night. The variability of blood pressure by day was inversely proportional to the sensitivity of the baroreflex (r = -0.33, P < .001), while the variability of heart period was directly related to the sensitivity of the reflex (r = 0.27, P < .01). Neither of these relationships was significant at night. An inverse relationship between heart period and blood pressure was shown by regression analysis of blood pressure and heart period averages over 24 h. The steepness of the slope of the heart period-systolic blood pressure relationship was strongly correlated with the baroreflex sensitivity (r = -0.55, P < .001), suggesting that blood pressure variations are substantially buffered by changes in heart frequency. Thus, a more stable heart rate that results from an ineffective baroreflex is associated with a more variable systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalAmerican Journal of Hypertension
Volume4
Issue number3 I
StatePublished - 1991
Externally publishedYes

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Blood Pressure
Hypertension
Baroreflex
Phenylephrine
Reflex
Heart Rate
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coats, A. J. S., Conway, J., Sleight, P., Meyer, T. E., Somers, V., Floras, J. S., & Jones, J. V. (1991). Interdependence of blood pressure and heart period regulation in mild hypertension. American Journal of Hypertension, 4(3 I), 234-238.

Interdependence of blood pressure and heart period regulation in mild hypertension. / Coats, A. J S; Conway, J.; Sleight, P.; Meyer, T. E.; Somers, Virend; Floras, J. S.; Jones, J. V.

In: American Journal of Hypertension, Vol. 4, No. 3 I, 1991, p. 234-238.

Research output: Contribution to journalArticle

Coats, AJS, Conway, J, Sleight, P, Meyer, TE, Somers, V, Floras, JS & Jones, JV 1991, 'Interdependence of blood pressure and heart period regulation in mild hypertension', American Journal of Hypertension, vol. 4, no. 3 I, pp. 234-238.
Coats AJS, Conway J, Sleight P, Meyer TE, Somers V, Floras JS et al. Interdependence of blood pressure and heart period regulation in mild hypertension. American Journal of Hypertension. 1991;4(3 I):234-238.
Coats, A. J S ; Conway, J. ; Sleight, P. ; Meyer, T. E. ; Somers, Virend ; Floras, J. S. ; Jones, J. V. / Interdependence of blood pressure and heart period regulation in mild hypertension. In: American Journal of Hypertension. 1991 ; Vol. 4, No. 3 I. pp. 234-238.
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