Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study

Carrie P. Aaron, Joseph E. Schwartz, Suzette J Bielinski, Eric A. Hoffman, John H M Austin, Elizabeth C. Oelsner, Kathleen M. Donohue, Ravi Kalhan, Cecilia Berardi, Joel D. Kaufman, David R. Jacobs, Russell P. Tracy, R. Graham Barr

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors. Results Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function. Conclusions Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.

Original languageEnglish (US)
Pages (from-to)255-264
Number of pages10
JournalRespiratory Medicine
Volume109
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Emphysema
Intercellular Adhesion Molecule-1
Atherosclerosis
E-Selectin
Lung
Neutrophils
Leukocyte Rolling
Anthropometry
Sphingomyelins
Spirometry
C-Reactive Protein
Chronic Obstructive Pulmonary Disease
Cardiovascular Diseases
Smoking
Demography
Population

Keywords

  • CT imaging
  • Emphysema
  • Endothelium
  • Intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Aaron, C. P., Schwartz, J. E., Bielinski, S. J., Hoffman, E. A., Austin, J. H. M., Oelsner, E. C., ... Barr, R. G. (2015). Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study. Respiratory Medicine, 109(2), 255-264. https://doi.org/10.1016/j.rmed.2014.10.004

Intercellular adhesion molecule 1 and progression of percent emphysema : The MESA Lung Study. / Aaron, Carrie P.; Schwartz, Joseph E.; Bielinski, Suzette J; Hoffman, Eric A.; Austin, John H M; Oelsner, Elizabeth C.; Donohue, Kathleen M.; Kalhan, Ravi; Berardi, Cecilia; Kaufman, Joel D.; Jacobs, David R.; Tracy, Russell P.; Barr, R. Graham.

In: Respiratory Medicine, Vol. 109, No. 2, 01.02.2015, p. 255-264.

Research output: Contribution to journalArticle

Aaron, CP, Schwartz, JE, Bielinski, SJ, Hoffman, EA, Austin, JHM, Oelsner, EC, Donohue, KM, Kalhan, R, Berardi, C, Kaufman, JD, Jacobs, DR, Tracy, RP & Barr, RG 2015, 'Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study', Respiratory Medicine, vol. 109, no. 2, pp. 255-264. https://doi.org/10.1016/j.rmed.2014.10.004
Aaron, Carrie P. ; Schwartz, Joseph E. ; Bielinski, Suzette J ; Hoffman, Eric A. ; Austin, John H M ; Oelsner, Elizabeth C. ; Donohue, Kathleen M. ; Kalhan, Ravi ; Berardi, Cecilia ; Kaufman, Joel D. ; Jacobs, David R. ; Tracy, Russell P. ; Barr, R. Graham. / Intercellular adhesion molecule 1 and progression of percent emphysema : The MESA Lung Study. In: Respiratory Medicine. 2015 ; Vol. 109, No. 2. pp. 255-264.
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abstract = "Background Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors. Results Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95{\%} CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95{\%} CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function. Conclusions Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.",
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T1 - Intercellular adhesion molecule 1 and progression of percent emphysema

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AU - Aaron, Carrie P.

AU - Schwartz, Joseph E.

AU - Bielinski, Suzette J

AU - Hoffman, Eric A.

AU - Austin, John H M

AU - Oelsner, Elizabeth C.

AU - Donohue, Kathleen M.

AU - Kalhan, Ravi

AU - Berardi, Cecilia

AU - Kaufman, Joel D.

AU - Jacobs, David R.

AU - Tracy, Russell P.

AU - Barr, R. Graham

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N2 - Background Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors. Results Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function. Conclusions Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.

AB - Background Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors. Results Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function. Conclusions Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.

KW - CT imaging

KW - Emphysema

KW - Endothelium

KW - Intercellular adhesion molecule-1

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