Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord.

R. D. Russell, J. B. Leslie, Y. F. Su, W. D. Watkins, K. J. Chang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Possible interactions between mu- and delta-receptors in the rat spinal cord were studied using the radiant-heat-induced tail flick response and the highly selective mu- or delta-ligands: [NMePhe3,D-Pro4] morphiceptin(PL-17) and cyclic[D-Pen2,D-Pen5]enkephalin(DPDPE). Intrathecal infusions of PL-17 (0.5 microgram/hr) for 5 days caused 61- and 6-fold shifts to the right of the dose-response curves for PL-17 and DPDPE, respectively. Since PL-17 and DPDPE are highly selective agonists for mu- and delta-receptors, the partial cross-tolerance to the delta-agonist induced by PL-17 is probably not resultant from a cross-reactivity between these ligands. These data suggest that there may be an interaction between mu- and delta-receptors in the rat spinal cord.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalNIDA research monograph
Volume75
StatePublished - 1986

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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