Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord.

R. D. Russell, J. B. Leslie, Y. F. Su, W. D. Watkins, K. J. Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Possible interactions between mu- and delta-receptors in the rat spinal cord were studied using the radiant-heat-induced tail flick response and the highly selective mu- or delta-ligands: [NMePhe3,D-Pro4] morphiceptin(PL-17) and cyclic[D-Pen2,D-Pen5]enkephalin(DPDPE). Intrathecal infusions of PL-17 (0.5 microgram/hr) for 5 days caused 61- and 6-fold shifts to the right of the dose-response curves for PL-17 and DPDPE, respectively. Since PL-17 and DPDPE are highly selective agonists for mu- and delta-receptors, the partial cross-tolerance to the delta-agonist induced by PL-17 is probably not resultant from a cross-reactivity between these ligands. These data suggest that there may be an interaction between mu- and delta-receptors in the rat spinal cord.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalNIDA research monograph
Volume75
StatePublished - 1986
Externally publishedYes

Fingerprint

Opioid Analgesics
D-Penicillamine (2,5)-Enkephalin
Spinal Cord
delta Opioid Receptor
mu Opioid Receptor
Ligands
Tail
Hot Temperature
N-Me-Phe(3)-morphiceptin

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Russell, R. D., Leslie, J. B., Su, Y. F., Watkins, W. D., & Chang, K. J. (1986). Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord. NIDA research monograph, 75, 97-100.

Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord. / Russell, R. D.; Leslie, J. B.; Su, Y. F.; Watkins, W. D.; Chang, K. J.

In: NIDA research monograph, Vol. 75, 1986, p. 97-100.

Research output: Contribution to journalArticle

Russell, RD, Leslie, JB, Su, YF, Watkins, WD & Chang, KJ 1986, 'Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord.', NIDA research monograph, vol. 75, pp. 97-100.
Russell, R. D. ; Leslie, J. B. ; Su, Y. F. ; Watkins, W. D. ; Chang, K. J. / Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord. In: NIDA research monograph. 1986 ; Vol. 75. pp. 97-100.
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