Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: Effect of 5-hydroxytryptamine 1 receptor agonism

E. L. Calvert, P. J. Whorwell, L. A. Houghton

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Little is known about the effect of 5-hydroxytryptamine 1 (5-HT1) receptor agonism on the co-ordinated motor activity of the gastric antrum, pylorus and duodenum under fasting and fed conditions. Aim: To evaluate the effect of sumatriptan, a 5-HT1 agonist, on fasting and fed antro-pyloro-duodenal motility. Methods: In study 1, antro-pyloro-duodenal motility was recorded for two phase IIIs of the migrating motor complex and then, following either a subcutaneous injection of sumatriptan 6 mg or saline control, for at least one additional phase III in 11 healthy volunteers (21-36 years). In study 2, the post-prandial motility was recorded for 3 h after either a subcutaneous injection of sumatriptan 6 mg or saline control in 10 healthy volunteers (18-36 years). Results: Sumatriptan prolonged the migrating motor complex cycle (P = 0.009) by increasing the duration of phase II (P = 0.02) but not phases I and III. Postprandially, sumatriptan reduced the activity index (P = 0.017) by reducing the frequency of co-ordinated motor activity involving the antrum and/or the duodenum (P < 0.05). Conclusion: 5-HT1 receptor agonism increases the periodicity of the migrating motor complex and reduces the occurrence of post-prandial co-ordinated motor activity involving the gastric antrum, pylorus and duodenum.

Original languageEnglish (US)
Pages (from-to)805-815
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume19
Issue number7
DOIs
StatePublished - Apr 1 2004

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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