Integrative biology of exercise

John A. Hawley, Mark Hargreaves, Michael Joseph Joyner, Juleen R. Zierath

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Exercise represents a major challenge to whole-body homeostasis provoking widespread perturbations in numerous cells, tissues, and organs that are caused by or are a response to the increased metabolic activity of contracting skeletal muscles. To meet this challenge, multiple integrated and often redundant responses operate to blunt the homeostatic threats generated by exercise-induced increases in muscle energy and oxygen demand. The application of molecular techniques to exercise biology has provided greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses, and recent discoveries offer perspectives on the mechanisms by which muscle "communicates" with other organs and mediates the beneficial effects of exercise on health and performance.

Original languageEnglish (US)
Pages (from-to)738-749
Number of pages12
JournalCell
Volume159
Issue number4
DOIs
StatePublished - Nov 6 2014

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Muscle
Muscles
Skeletal Muscle
Homeostasis
Oxygen
Health
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014). Integrative biology of exercise. Cell, 159(4), 738-749. https://doi.org/10.1016/j.cell.2014.10.029

Integrative biology of exercise. / Hawley, John A.; Hargreaves, Mark; Joyner, Michael Joseph; Zierath, Juleen R.

In: Cell, Vol. 159, No. 4, 06.11.2014, p. 738-749.

Research output: Contribution to journalArticle

Hawley, JA, Hargreaves, M, Joyner, MJ & Zierath, JR 2014, 'Integrative biology of exercise', Cell, vol. 159, no. 4, pp. 738-749. https://doi.org/10.1016/j.cell.2014.10.029
Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 6;159(4):738-749. https://doi.org/10.1016/j.cell.2014.10.029
Hawley, John A. ; Hargreaves, Mark ; Joyner, Michael Joseph ; Zierath, Juleen R. / Integrative biology of exercise. In: Cell. 2014 ; Vol. 159, No. 4. pp. 738-749.
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