Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status

Jolanta Lissowska, Mia M. Gaudet, Louise A. Brinton, Beata Peplonska, Mark Sherman, Neonila Szeszenia-Dabrowska, Witold Zatonski, Montserrat Garcia-Closas

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We evaluated this hypothesis in a large (2,386 cases and 2,503 controls) population-based case-control study in Poland, conducted between 2000 and 2003. We observed significant associations between reduced overall risk of breast cancer and increasing levels of total fruit intake (odds ratio (OR) for highest versus lowest quartile = 0.76, 95%CI = 0.63-0.91; p-trend = 0.01), but not for total vegetable intake (1.13 (0.93-1.37), p-trend = 0.25), after controlling for age, energy intake and known risk factors for breast cancer. The inverse association with total fruit intake was stronger for risk of ER+ (0.69 (0.54-0.88), p-trend = 0.01) than ER- tumors (0.89 (0.67-1.19), p-trend = 0.57) (p-heterogeneity = 0.02). In conclusion, this study suggests that fruit intake might have differential associations for breast tumor subtypes defined by ER status.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalBreast Cancer Research and Treatment
Volume107
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Breast cancer risk
  • Estrogen receptor
  • Fruit
  • Progesterone receptor
  • Vegetables

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status'. Together they form a unique fingerprint.

  • Cite this

    Lissowska, J., Gaudet, M. M., Brinton, L. A., Peplonska, B., Sherman, M., Szeszenia-Dabrowska, N., Zatonski, W., & Garcia-Closas, M. (2008). Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status. Breast Cancer Research and Treatment, 107(1), 113-117. https://doi.org/10.1007/s10549-007-9524-9