TY - JOUR
T1 - Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status
AU - Lissowska, Jolanta
AU - Gaudet, Mia M.
AU - Brinton, Louise A.
AU - Peplonska, Beata
AU - Sherman, Mark
AU - Szeszenia-Dabrowska, Neonila
AU - Zatonski, Witold
AU - Garcia-Closas, Montserrat
N1 - Funding Information:
Acknowledgements We thank Tea Zimmerman (Westat, Rockville, MD) and Jane Curtin (IMS, Silver Spring, MD) for their help in transforming recipes of Polish foods and dishes into nutrients. We thank Anita Soni and Elena Adrianza (Westat, Rockville, MD) for study management; Pei Chao (IMS, Silver Spring, MD) for data and sample management. Field work for the study was overseen by Drs. Edward Towpik and Jerzy Giermek, Breast Cancer Treatment and Reconstruction Clinic, Cancer Center, Warsaw; Dr. Pawel Kukawski, Department of Surgical Oncology, M. Sklodowska-Curie Institute of Oncology, Warsaw; Drs. Arkadiusz Jeziorski and Janusz Piekarski, Medical University, Oncology Clinic, Lódź; Drs Zbigniew Morawiec and Mariusz Pawlak, Community Copernicus Hospital, Lódź; and Drs. Marcin Faflik, Magdalena Baklinska, Marek Zadrozny and Boguslaw Westfal, Departments of Surgical Oncology and Breast Diseases, Polish Mother’s Health Memorial Hospital, Łódź. Preparation of pathologic study specimens was provided by Drs. Wlodzimierz Olszewski, Grzegorz Rymkiewicz, Dorota Mazepa-Sikora,. Marcin Ligaj, Joanna Baraska and Agnieszka Turowicz in Warsaw and Stanislaw Lukaszek, Andrzej Kulig, Radzislaw Kordek, Grazyna Pasz-Walczak, Robert Kubiak, Dorota Kupnicka and Boguslaw Olborski in Lódź. We also thank the nurses, interviewers and study participants for their contributions to this study. This research was supported by the Intramural Research Program of NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics.
PY - 2008/1
Y1 - 2008/1
N2 - The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We evaluated this hypothesis in a large (2,386 cases and 2,503 controls) population-based case-control study in Poland, conducted between 2000 and 2003. We observed significant associations between reduced overall risk of breast cancer and increasing levels of total fruit intake (odds ratio (OR) for highest versus lowest quartile = 0.76, 95%CI = 0.63-0.91; p-trend = 0.01), but not for total vegetable intake (1.13 (0.93-1.37), p-trend = 0.25), after controlling for age, energy intake and known risk factors for breast cancer. The inverse association with total fruit intake was stronger for risk of ER+ (0.69 (0.54-0.88), p-trend = 0.01) than ER- tumors (0.89 (0.67-1.19), p-trend = 0.57) (p-heterogeneity = 0.02). In conclusion, this study suggests that fruit intake might have differential associations for breast tumor subtypes defined by ER status.
AB - The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We evaluated this hypothesis in a large (2,386 cases and 2,503 controls) population-based case-control study in Poland, conducted between 2000 and 2003. We observed significant associations between reduced overall risk of breast cancer and increasing levels of total fruit intake (odds ratio (OR) for highest versus lowest quartile = 0.76, 95%CI = 0.63-0.91; p-trend = 0.01), but not for total vegetable intake (1.13 (0.93-1.37), p-trend = 0.25), after controlling for age, energy intake and known risk factors for breast cancer. The inverse association with total fruit intake was stronger for risk of ER+ (0.69 (0.54-0.88), p-trend = 0.01) than ER- tumors (0.89 (0.67-1.19), p-trend = 0.57) (p-heterogeneity = 0.02). In conclusion, this study suggests that fruit intake might have differential associations for breast tumor subtypes defined by ER status.
KW - Breast cancer risk
KW - Estrogen receptor
KW - Fruit
KW - Progesterone receptor
KW - Vegetables
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UR - http://www.scopus.com/inward/citedby.url?scp=36549058166&partnerID=8YFLogxK
U2 - 10.1007/s10549-007-9524-9
DO - 10.1007/s10549-007-9524-9
M3 - Article
C2 - 17318377
AN - SCOPUS:36549058166
SN - 0167-6806
VL - 107
SP - 113
EP - 117
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -