Intact and altered endothelium in regulation of vasomotion

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

The endothelium possesses the ability to modulate vascular tone by the release of vasodilator and vasoconstrictor substances, among them endothelium-derived relaxing factor (EDRF) and endothelin. Abnormalities in EDRF generation were demonstrated in various cardiovascular pathophysiological states, specifically atherosclerotic vascular disease, congestive heart failure, and essential and pulmonary hypertension. Moreover, increases in plasma endothelin concentration have been reported as well in these disease states. When these observations are taken together, these states may be characterized by an attenuated release of EDRF, whereas the release of endothelin is augmented. An imbalance between EDRF and endothelin may contribute to the alteration in vascular tone characteristic of cardiovascular disease. The following review summarizes the present knowledge of the role of EDRF and endothelin in such disease processes.

Original languageEnglish (US)
JournalCirculation
Volume86
Issue number6 SUPPL.
StatePublished - 1992

Fingerprint

Endothelium-Dependent Relaxing Factors
Endothelins
Endothelium
Blood Vessels
Vasoconstrictor Agents
Vasodilator Agents
Vascular Diseases
Pulmonary Hypertension
Cardiovascular Diseases
Heart Failure

Keywords

  • endothelin
  • endothelium-derived relaxing factor
  • vascular resistance

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Intact and altered endothelium in regulation of vasomotion. / Lerman, Amir; Burnett, John C Jr.

In: Circulation, Vol. 86, No. 6 SUPPL., 1992.

Research output: Contribution to journalArticle

@article{32927b45034e45f1a05e6fbd6c21beed,
title = "Intact and altered endothelium in regulation of vasomotion",
abstract = "The endothelium possesses the ability to modulate vascular tone by the release of vasodilator and vasoconstrictor substances, among them endothelium-derived relaxing factor (EDRF) and endothelin. Abnormalities in EDRF generation were demonstrated in various cardiovascular pathophysiological states, specifically atherosclerotic vascular disease, congestive heart failure, and essential and pulmonary hypertension. Moreover, increases in plasma endothelin concentration have been reported as well in these disease states. When these observations are taken together, these states may be characterized by an attenuated release of EDRF, whereas the release of endothelin is augmented. An imbalance between EDRF and endothelin may contribute to the alteration in vascular tone characteristic of cardiovascular disease. The following review summarizes the present knowledge of the role of EDRF and endothelin in such disease processes.",
keywords = "endothelin, endothelium-derived relaxing factor, vascular resistance",
author = "Amir Lerman and Burnett, {John C Jr.}",
year = "1992",
language = "English (US)",
volume = "86",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "6 SUPPL.",

}

TY - JOUR

T1 - Intact and altered endothelium in regulation of vasomotion

AU - Lerman, Amir

AU - Burnett, John C Jr.

PY - 1992

Y1 - 1992

N2 - The endothelium possesses the ability to modulate vascular tone by the release of vasodilator and vasoconstrictor substances, among them endothelium-derived relaxing factor (EDRF) and endothelin. Abnormalities in EDRF generation were demonstrated in various cardiovascular pathophysiological states, specifically atherosclerotic vascular disease, congestive heart failure, and essential and pulmonary hypertension. Moreover, increases in plasma endothelin concentration have been reported as well in these disease states. When these observations are taken together, these states may be characterized by an attenuated release of EDRF, whereas the release of endothelin is augmented. An imbalance between EDRF and endothelin may contribute to the alteration in vascular tone characteristic of cardiovascular disease. The following review summarizes the present knowledge of the role of EDRF and endothelin in such disease processes.

AB - The endothelium possesses the ability to modulate vascular tone by the release of vasodilator and vasoconstrictor substances, among them endothelium-derived relaxing factor (EDRF) and endothelin. Abnormalities in EDRF generation were demonstrated in various cardiovascular pathophysiological states, specifically atherosclerotic vascular disease, congestive heart failure, and essential and pulmonary hypertension. Moreover, increases in plasma endothelin concentration have been reported as well in these disease states. When these observations are taken together, these states may be characterized by an attenuated release of EDRF, whereas the release of endothelin is augmented. An imbalance between EDRF and endothelin may contribute to the alteration in vascular tone characteristic of cardiovascular disease. The following review summarizes the present knowledge of the role of EDRF and endothelin in such disease processes.

KW - endothelin

KW - endothelium-derived relaxing factor

KW - vascular resistance

UR - http://www.scopus.com/inward/record.url?scp=0026494483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026494483&partnerID=8YFLogxK

M3 - Article

C2 - 1424046

AN - SCOPUS:0026494483

VL - 86

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 6 SUPPL.

ER -